Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 1;25(19):e202400099.
doi: 10.1002/cbic.202400099. Epub 2024 Jul 26.

From the Design of Innovative Ti-Pt Heterometallic Complexes to the Development of Highly Anti-Proliferative Water-Soluble Cationic Titanocenes

Audrey Trommenschlager  1 , Nesrine Mabrouk  2 , Cindy Racoeur  2 , Amélie Godard  1 , Cédric Balan  1 , Laurence Dubrez  3 , Ali Bettaïeb  2 , Jérôme Husson  4 , Pierre Le Gendre  1 , Catherine Paul  2 , Ewen Bodio  1
Affiliations

From the Design of Innovative Ti-Pt Heterometallic Complexes to the Development of Highly Anti-Proliferative Water-Soluble Cationic Titanocenes

Audrey Trommenschlager et al. Chembiochem. .

Abstract

Two innovative early/late Ti-Pt-heterobimetallic complexes were synthesized, characterized, and screened in cell-based assays using several human (SW480 and MDA-MB-231) and murine cancer cell lines (CT26 and EMT6) as well as a non-cancerous cell line (HMEC). The combination of the two metals - titanium(IV) and platinum (IV) - in a single molecule led to a synergistic biological activity (higher anti-proliferative properties than a mixture of each of the corresponding monometallic complexes). This study also investigated the benefits of associating a metal-free terpyridine moiety (with intrinsic biological activity) with a water-soluble titanocene fragment. The present work reveals that these combinations results in water-soluble titanocene compounds displaying an anti-proliferative activity down to the submicromolar level. One of these complexes induced an antitumor effect in vivo in CT26 tumor bearing BALB/C mice. The terpyridine moiety was also used to track the complex in vitro by multiphoton microscopy imaging.

Keywords: bimetallic complex; cancer; platinum; theranostic; titanocene; water-soluble titanocene.

PubMed Disclaimer

References

    1. S. Abdolmaleki, A. Aliabadi, S. Khaksar, Coord. Chem. Rev. 2024, 501, 215579.
    1. L. Todorov, I. Kostova, Molecules 2023, 28, 1959.
    1. Á. M. Alsina-Sánchez, S. Montalvo-Vázquez, N. Grafals-Ruiz, C. Acosta, E. M. Ormé, I. Rodríguez, S. M. Delgado-Rivera, A. D. Tinoco, S. Dharmawardhane, I. C. Montes-González, ACS Omega 2023, 8, 34377–34387.
    1. S. Sen, M. Won, M. S. Levine, Y. Noh, A. C. Sedgwick, J. S. Kim, J. L. Sessler, J. F. Arambula, Chem. Soc. Rev. 2022, 51, 1212–1233.
    1. Y. Lu, X. Ma, X. Chang, Z. Liang, L. Lv, M. Shan, Q. Lu, Z. Wen, R. Gust, W. Liu, Chem. Soc. Rev. 2022, 51, 5518–5556.

MeSH terms

LinkOut - more resources