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. 2023 Oct:2023:10.1109/bsn58485.2023.10331081.
doi: 10.1109/bsn58485.2023.10331081. Epub 2023 Dec 1.

A New Technique to Estimate the Cole Model for Bio-impedance Spectroscopy with the High-Frequency Characteristics Estimation

Sina Razaghi  1 , Ebenezer Asabre  1 , Abu Bony Amin  1 , Yeonsik Noh  1   2
Affiliations

A New Technique to Estimate the Cole Model for Bio-impedance Spectroscopy with the High-Frequency Characteristics Estimation

Sina Razaghi et al. Int Conf Wearable Implant Body Sens Netw. 2023 Oct.

Abstract

Bio-impedance spectroscopy (BIS) is a sophisticated testing technique used to analyze impedance changes at different frequencies. In this study, we investigated the estimation of the Cole Model for BIS measurements without the need for high-frequency resistance and reactance measurements, where they are inaccurate due to leakage capacitences. We employed a Texas Instruments evaluation kit (AFE4300) and compared the Cole plots of two different circuit models of tissue between the proposed configuration and a commercial impedance analyzer used as a reference. To enhance the performance of the AFE4300, we incorporated an external direct digital synthesis (DDS) to generate higher frequencies. The results demonstrated the reliability of the proposed theoretical estimation technique in accurately estimating the resistances and capacitance of the Cole Model.

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Figures

Fig. 1.
Fig. 1.
(a) Proposed Circuit Model Representing the Tissue Model (b) Replacement of an External DDS in AFE4300 Evaluation Board
Fig. 2.
Fig. 2.
(a) Cole Plot of Three Different Circuit Models, Recorded by Reference Impedance Analyzer Device (Showing the Variations in the range of 1 kHz - 1 MHz) (b) Variations in the Real Part of the Impedance for Three Circuit Models
Fig. 3.
Fig. 3.
(a) Cole - Cole Plot Based on the Digital Output Codes of AFE4300 Board in frequency range of 1 kHz - 275 kHz (b) Cole - Cole Plot Based on the Digital Output Codes of AFE4300 Board in frequency range of 1 kHz - 485 kHz (c) Unreliable frequency ranges based on the variation of I code of evaluation board (d) Unreliable frequency ranges based on the variation of Q code of evaluation board (e) Calibration of the I code and (f) Calibration of the Q code Based on the available Reference Values
Fig. 4.
Fig. 4.
(a) Illustration of the error rate in Model 1 (b) Illustration of the error rate in Model 2
Fig. 5.
Fig. 5.
(a) Variations of the calibrated Impedance and phase in Model 1 (b) Showing the Peak frequency based on the Final Calibrated Cole-Cole Plot
Fig. 6.
Fig. 6.
Estimated Cole Plot for f Range of 1 kHz to 1 MHz in Model 1
See this image and copyright information in PMC

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