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Editorial
. 2024 Apr 24:5:16.
doi: 10.21037/tbcr-23-53. eCollection 2024.

New role for GCH1 in cancer

Shane J F Cronin  1
Affiliations
Editorial

New role for GCH1 in cancer

Shane J F Cronin. Transl Breast Cancer Res. .
No abstract available

Keywords: BH4; GTP cyclohydrolase I (GCH1); breast cancer; epithelial-mesenchymal transition (EMT); sepiapterin reductase (SPR).

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Conflict of interest statement

Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://tbcr.amegroups.org/article/view/10.21037/tbcr-23-53/coif). The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
GCH1 induces EMT independent of its BH4-synthesizing activity. In addition to its canonical enzymatic role in synthesizing BH4 which promotes cancer in by itself ①, GCH1 has now been shown to bind and stabilize Vimentin, and in doing so promote epithelial-mesenchymal transitioning ②. By understanding these distinct functions of GCH1, it opens novel specific, or combinatorial, therapeutic breast cancer treatment options which can target mechanistic routes 1 or 2, or both. GCH1, GTP cyclohydrolase I; EGFR, epidermal growth factor receptor; EMT, epithelial-mesenchymal transition.
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References

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