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Review
. 2024 Jul;43(7):1475-1480.
doi: 10.1007/s10096-024-04849-0. Epub 2024 May 16.

Dalbavancin as suppressive therapy for implant-related infections: a case series with therapeutic drug monitoring and review of the literature

Barthelemy Lafon-Desmurs  1 , Benoit Gachet  2   3 , Benjamin Hennart  4 , Benjamin Valentin  5 , Gabrielle Roosen  6 , Maxime Degrendel  2 , Caroline Loiez  7 , Eric Beltrand  8 , Piervito D'Elia  9 , Henri Migaud  10 , Olivier Robineau  2   3   11 , Eric Senneville  2
Affiliations
Review

Dalbavancin as suppressive therapy for implant-related infections: a case series with therapeutic drug monitoring and review of the literature

Barthelemy Lafon-Desmurs et al. Eur J Clin Microbiol Infect Dis. 2024 Jul.

Abstract

Implant-related infections may need suppressive antibiotic therapy (SAT). We describe a SAT strategy using dalbavancin with therapeutic drug monitoring (TDM). This is a retrospective bicentric study of patients with implant-related infection who received dalbavancin SAT between January 2021 and September 2023. Fifteen patients were included. Median number of injections was 4 (IQR: 2-7). Median time between two reinjections was 57 days (IQR 28-82). Dalbavancin plasma concentrations were above 4 mg/L for 97.9% of dosages (93/95) and above 8 mg/L for 85% (81/95). These results support the use of dalbavancin SAT for implant-related infections.

Keywords: Dalbavancin; Dosage; Prosthetic joint infection; Suppressive therapy; Vascular graft infection.

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