Studies with temocillin in a hamster model of antibiotic-associated colitis
- PMID: 3875312
- PMCID: PMC180203
- DOI: 10.1128/AAC.27.6.980
Studies with temocillin in a hamster model of antibiotic-associated colitis
Abstract
Hamsters given the new penicillin temocillin, either orally or by injection, did not develop antibiotic-associated colitis, whereas animals given the control antibiotics cefoxitin or clindamycin developed the disease, which is characterized by marked hemorrhagic cecitis and high cecal levels of Clostridium difficile cytotoxin.
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