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Randomized Controlled Trial
. 2024 Jul;12(6):772-779.
doi: 10.1002/ueg2.12577. Epub 2024 May 16.

Optical enhancement mode 2 improves the detection rate of gastric neoplastic lesion in high-risk populations: A multicenter randomized controlled clinical study

Wei An  1 , Qi Wu  2 , Xiao-Ju Su  1 , Hong-Xin Sun  1 , Jing Wang  2 , Wei-Jia Dou  3 , Zhen-Xiong Liu  3 , Gai-Fang Liu  4 , Yue-Han Zhang  4 , Shu-Chang Xu  5 , Ying Chen  5 , Hao Zhang  6 , Bin Zhang  6 , Ping Li  7 , Si-Yu Sun  8 , Sheng Wang  8 , Wen Liu  8 , Xiao-Feng Zhang  9 , Yu-Shu Zhang  10 , Yi-Jun Xu  10 , Mei Liu  11 , Xin-Xia Feng  11 , Xiu-Li Zuo  12 , Guang-Chao Li  12 , Li-Dong Xu  13 , Dong Wang  14 , Xin-Gang Shi  1 , Liang-Hao Hu  1 , Zhao-Shen Li  1
Affiliations
Randomized Controlled Trial

Optical enhancement mode 2 improves the detection rate of gastric neoplastic lesion in high-risk populations: A multicenter randomized controlled clinical study

Wei An et al. United European Gastroenterol J. 2024 Jul.

Abstract

Objectives: Detection of early neoplastic lesions is crucial for improving the survival rates of patients with gastric cancer. Optical enhancement mode 2 is a new image-enhanced endoscopic technique that offers bright images and can improve the visibility of neoplastic lesions. This study aimed to compare the detection of neoplastic lesions with optical enhancement mode 2 and white-light imaging (WLI) in a high-risk population.

Methods: In this prospective multicenter randomized controlled trial, patients were randomly assigned to optical enhancement mode 2 or WLI groups. Detection of suspicious neoplastic lesions during the examinations was recorded, and pathological diagnoses served as the gold standard.

Results: A total of 1211 and 1219 individuals were included in the optical enhancement mode 2 and WLI groups, respectively. The detection rate of neoplastic lesions was significantly higher in the optical enhancement mode 2 group (5.1% vs. 1.9%; risk ratio, 2.656 [95% confidence interval, 1.630-4.330]; p < 0.001). The detection rate of neoplastic lesions with an atrophic gastritis background was significantly higher in the optical enhancement mode 2 group (8.6% vs. 2.6%, p < 0.001). The optical enhancement mode 2 group also had a higher detection rate among endoscopists with different experiences.

Conclusions: Optical enhancement mode 2 was more effective than WLI for detecting neoplastic lesions in the stomach, and can serve as a new method for screening early gastric cancer in clinical practice.

Clinical registry: United States National Library of Medicine (https://www.

Clinicaltrials: gov), ID: NCT040720521.

Keywords: early gastric cancer; endoscopic screening.

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Conflict of interest statement

The authors declare that they have no conflicts of interest for this article.

Figures

FIGURE 1
FIGURE 1
Flowchart showing recruitment of patients in this study.
FIGURE 2
FIGURE 2
Typical pictures of early cancer under white‐light imaging and OE‐2 mode.
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. 10.3322/caac.21660 - DOI - PubMed
    1. Sekiguchi M, Oda I, Matsuda T, Saito Y. Epidemiological trends and future perspectives of gastric cancer in eastern asia. Digestion. 2022;103(1):22–28. 10.1159/000518483 - DOI - PubMed
    1. Xu H, Li W. Early detection of gastric cancer in China: progress and opportunities. Cancer Biol Med. 2022;19(12):1622–1628. 10.20892/j.issn.2095-3941.2022.0655 - DOI - PMC - PubMed
    1. Jang JY. The past, present, and future of image‐enhanced endoscopy. Clin Endosc. 2015;48(6):466–475. 10.5946/ce.2015.48.6.466 - DOI - PMC - PubMed
    1. Muto M, Minashi K, Yano T, Saito Y, Oda I, Nonaka S, et al. Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial. J Clin Oncol. 2010;28(9):1566–1572. 10.1200/jco.2009.25.4680 - DOI - PMC - PubMed

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