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Case Reports
. 2024 Aug 1;43(8):e282-e284.
doi: 10.1097/INF.0000000000004397. Epub 2024 May 10.

Severe Meningococcal Meningitis Revealing a Novel Form of Properdin Deficiency in a Previously Healthy 13-Year-old Child

Martina Bevacqua  1 , Paul Bastard  2   3   4   5 , Yael Pinhas  1 , Mélodie Aubart  3   6 , Charles-Joris Roux  7 , Muhamed-Kheir Taha  8 , Jérémie F Cohen  1
Affiliations
Case Reports

Severe Meningococcal Meningitis Revealing a Novel Form of Properdin Deficiency in a Previously Healthy 13-Year-old Child

Martina Bevacqua et al. Pediatr Infect Dis J. .

Abstract

A 13-year-old boy was admitted with severe meningococcal meningitis. Immunologic workup revealed a properdin deficiency, and genetic sequencing of CFP identified a novel, private and predicted pathogenic variant in exon 8. The patient received broad immunizations and penicillin prophylaxis. Children with invasive meningococcal disease should be tested for complement deficiency.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Wang B, Santoreneos R, Giles L, et al. Case fatality rates of invasive meningococcal disease by serogroup and age: a systematic review and meta-analysis. Vaccine. 2019;37:2768–2782.
    1. ECDC. Invasive Meningococcal Disease. Stockholm; 2022.
    1. Parikh SR, Campbell H, Bettinger JA, et al. The everchanging epidemiology of meningococcal disease worldwide and the potential for prevention through vaccination. J Infect. 2020;81:483–498.
    1. Pettigrew HD, Teuber SS, Gershwin ME. Clinical significance of complement deficiencies. Ann N Y Acad Sci. 2009;1173:108–123.
    1. Emonts M, Hazelzet JA, de Groot R, et al. Host genetic determinants of Neisseria meningitidis infections. Lancet Infect Dis. 2003;3:565–577.

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