Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 15:79:100385.
doi: 10.1016/j.clinsp.2024.100385. eCollection 2024.

Changes of GH-IGFs and its relationship with growth retardation in children with bronchial asthma

Li Li  1 , Lihua Qiu  2 , Junchao Xia  1 , Yichun Xiao  1 , Li Zhao  3 , Haiyan Wang  4
Affiliations

Changes of GH-IGFs and its relationship with growth retardation in children with bronchial asthma

Li Li et al. Clinics (Sao Paulo). .

Abstract

Objective: To explore the relationship between Growth Hormone Insulin-like Growth Factors (GH-IGFs) and growth retardation in children with bronchial asthma.

Methods: 112 children with bronchial asthma and 50 healthy children were studied. Serum GH, IGF-1, and Insulin-like Growth Factor Binding Protein 3 (IGFBP3) were assessed by ELISA. GH-IGFs-related parameters were compared, and the correlation between the parameters and bronchial asthma severity was analyzed. The bronchial asthma group was divided into the growth retardation group and non-growth retardation group to analyze the diagnostic value of GH-IGFs in growth retardation and the relationship between GH-IGFs and growth retardation.

Results: GH, IGF-1, and IGFBP3 in the bronchial asthma group were lower. GH, IGF-1, and IGFBP3 levels were decreased with the severity of bronchial asthma. GH, IGF-1, and IGFBP3 in the growth retardation group were lower than those in the non-growth retardation group. The AUC of GH-IGFs combined detection was higher than that of GH and IGFBP3 alone detection. GH < 9.27 μg/L and IGF-1 < 179.53 mmoL/L were risk factors for growth retardation in patients with bronchial asthma.

Conclusion: GH-IGFs-related parameters have diagnostic value for growth retardation in children, and decreased levels of GH and IGF-1 are risk factors for growth retardation in children.

Keywords: Children Bronchial Asthma; Growth Hormone; Growth Retardation; Insulin-like Growth Factor Binding Protein 3; Insulin-like Growth Factor Ⅰ.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interest.

Figures

Fig 1
Fig. 1
GH-IGFs-related parameters in bronchial asthma.
Fig 2
Fig. 2
GH-IGFs-related parameters in patients with different severity of bronchial asthma.
Fig 3
Fig. 3
Correlation analysis between GH-IGFs-related parameters and severity of bronchial asthma.
Fig 4
Fig. 4
GH-IGFs-related parameters in patients with or without growth retardation.
Fig 5
Fig. 5
ROC curve analysis of GH-IGFs-related indicators in diagnosis of growth retardation in children with bronchial asthma. Note: Comparison between the two groups (*p < 0.05).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Xie X, Xu D, Zhuang L, Liu H, Tan S, Lu Y, et al. Sanfu herbal patch applied at acupoints in patients with bronchial asthma: study protocol for a randomized controlled trial. Trials. 2020;21(1):684–689. - PMC - PubMed
    1. Liu Y, Nelson MV, Bailey C, Zhang P, Zheng P, Dome JS, et al. Correction: Targeting the HIF-1α-IGFBP2 axis therapeutically reduces IGF1-AKT signaling and blocks the growth and metastasis of relapsed anaplastic Wilms tumor. Oncogene. 2022;41(9):1383–1405. - PubMed
    1. Bagheri-Hosseinabadi Z, Rezazadeh Zarandi E, Mirabzadeh M, Amiri A, Abbasifard M. mRNA expression of toll-like receptors 3, 7, 8, and 9 in the nasopharyngeal epithelial cells of coronavirus disease 2019 patients. BMC Infect Dis. 2022;22(1):448–453. - PMC - PubMed
    1. Salama RH, Rasheed Z, Ahmed AA, Bin Saif GA, Elkholy MM, El-Moniem AEA, et al. Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy. Nucleosides Nucleotides Nucleic Acids. 2021;40(3):357–367. - PubMed
    1. Andersson CK, Iwasaki J, Cook J, Robinson P, Nagakumar P, Mogren S, et al. Impaired airway epithelial cell wound้ealing capacity is associated with airway remodelling following RSV infection in severe preschool wheeze. Allergy. 2020;75(12):3195–3207. - PMC - PubMed

Publication types

Substances