Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Jun;4(6):1435-40.
doi: 10.1002/j.1460-2075.1985.tb03799.x.

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts

L M Matrisian, N Glaichenhaus, M C Gesnel, R Breathnach

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts

L M Matrisian et al. EMBO J. 1985 Jun.

Abstract

We have isolated and sequenced a cloned cDNA corresponding to an mRNA present in significantly higher levels in rat cells transformed by polyoma virus, Rous sarcoma virus, and the cellular oncogene H-ras than in the normal parental cell lines. The mRNA transcript is also rapidly induced by the polypeptide growth factor epidermal growth factor, providing a new link between oncogenes and growth factors. Both the growth factor and the oncogenes control expression of the corresponding gene at the transcriptional level. Our results point to the existence of intracellular mechanisms that are common to the action of both growth factors and oncogenes.

PubMed Disclaimer

References

    1. J Biol Chem. 1972 Dec 10;247(23):7609-11 - PubMed
    1. Nucleic Acids Res. 1985 Feb 11;13(3):711-26 - PubMed
    1. J Virol. 1977 Dec;24(3):721-8 - PubMed
    1. Nature. 1977 Nov 24;270(5635):314-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed

Publication types

Associated data