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Review
. 2025 Jan;45(1):47-60.
doi: 10.1002/jat.4630. Epub 2024 May 16.

The marijuana, cannabinoids, and female reproductive system

Leila Najafi  1 , Zia Moasses  1 , Soghra Bahmanpour  2   3
Affiliations
Review

The marijuana, cannabinoids, and female reproductive system

Leila Najafi et al. J Appl Toxicol. 2025 Jan.

Abstract

The marijuana is considered as widely used recreational illicit drug that has become popular among women of reproductive age. It is believed that the marijuana use may have negative impacts on the female fertility. However, the exact mechanisms of its reproductive toxicity remain unclear. The studies suggest that the exogenous cannabinoids may interfere with endocannabinoid system and disrupt hypothalamic-pituitary-ovary axis. Consequently, it impacts the female fertility by disruption of normal secretion of ovarian sex hormones and menstrual cycles. However, other studies have shown that medical marijuana is useful analgesic agent for pain management. But, given that the wide range of cannabinoids side effects are reported, it seems that caution should be taken in the recreational use of these substances. In summary, this article aimed to review the possible impacts of marijuana and its derivatives on the main female reproductive organs and embryonic growth and development.

Keywords: cannabis; female reproductive system; infertility; marijuana.

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References

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