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. 2024 Aug 1;34(4):839-846.
doi: 10.1093/eurpub/ckae084.

Analysis of the global burden of cervical cancer in young women aged 15-44 years old

Min Zhang  1   2 , Jiayi Chen  3 , Meimei Cui  1   4 , Jingjing Jia  1   5 , Ming Zhao  1   2 , Dan Zhou  1   2 , Liling Zhu  2 , Limei Luo  1
Affiliations

Analysis of the global burden of cervical cancer in young women aged 15-44 years old

Min Zhang et al. Eur J Public Health. .

Abstract

Background: Understanding the burden of cervical cancer (CC) in young women aged 15-44 years old are essential for formulating effective preventive strategies.

Methods: Utilizing the Global Burden of Disease 2019 Study, we estimated incidence, disability-adjusted life-years (DALYs), years of life lost (YLLs) and years lived with disability (YLDs) due to CC among young women from 1990 to 2019. Additionally, we evaluated the temporal trends using estimated annual percentage changes (EAPCs) during this period. We conducted a decomposition analysis to assess the absolute contributions of three components: population growth, population age structure and epidemiologic changes.

Results: Globally, there were 187 609.22 incident cases of CC worldwide, resulting in 2621 917.39 DALYs in 2019. From1990 to 2019, the age-standardized rates were decline, only the age-standardized YLDs rate (EAPC = 0.02; 95% CI: -0.02 to 0.05) showed a stable trend. The largest increase in age-standardized incidence rate (ASIR) and age-standardized YLDs rate observed in the high-middle social demographic index (SDI) quintiles. Population growth and age structure changes were associated with substantial changes in cases of CC, especially in South Asia and East Asia.

Conclusions: Globally, the burden of CC in young women continues to increase, as measured by the absolute number. As populations are growing and age structure changes were associated with substantial changes in cases of CC, governments will face increasing demand for treatment, and support services for CC, especially in South Asia and East Asia.

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Figures

Figure 1
Figure 1
The distribution of cases of CC among young women worldwide in 1990 and 2019, and time trends from 1990 to 2019. (a) Incident cases, (b) disability-adjusted life years (DALYs). (c) The temporal trends using annual percentage changes (EAPCs). SDI, sociodemographic index.
Figure 2
Figure 2
Age-standardized burden of CC among young women across 204 countries in 2019. (a) age-standardized incidence rate (ASIR), (b) age-standardized disability-adjusted life years (DALYs) rate.
Figure 3
Figure 3
Decomposition of the percentage changes in CC among young women worldwide from 1990 to 2019. (a) Incidence, (b) disability-adjusted life years (DALYs). SDI, sociodemographic index.
See this image and copyright information in PMC

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