Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 1;10(9):e30564.
doi: 10.1016/j.heliyon.2024.e30564. eCollection 2024 May 15.

Hospitalization determinants in patients with Mpox disease: The CEME-22 Project

G Ramírez Olivencia  1 , M M Vera García  2 , M Velasco Arribas  3 , J Casabona  4 , M J Martínez  5 , F J Membrillo De Novales  1 ; CEME-22 Study Group. Study Group team members are listed in the Acknowledgments
Affiliations

Hospitalization determinants in patients with Mpox disease: The CEME-22 Project

G Ramírez Olivencia et al. Heliyon. .

Abstract

Objectives: This sub-analysis seeks to delineate and characterize factors influencing hospitalization in individuals diagnosed with Mpox disease amidst the initial outbreak in Spain in the onset of 2022.

Methods: Employing a non-probabilistic convenience sampling approach, a retrospective multicenter investigation was carried out to examine Monkeypox virus infection within Spanish healthcare facilities.

Results: The median duration of the disease was 16 days, with 4.2 % of cases resulting in hospitalization. There was a single ICU admission leading to fatality. Sequelae were observed in 2.3 % of cases. Multivariate analysis revealed that hospitalization decisions were influenced by immunosuppression and severe symptoms, including gastrointestinal, neurological, ear-nose-throat, and respiratory manifestations. Significant analytical parameter differences were restricted to hemoglobin levels at diagnosis.

Conclusions: This study elucidates factors influencing hospitalization decisions for Monkeypox patients in Spain, emphasizing the importance of immunosuppression and extracutaneous symptoms involving the gastrointestinal, ear-nose-throat, and respiratory pathways. In summary, hospitalization determinations arise from the interplay of these crucial dimensions.

Keywords: Healthcare facilities; Hospitalization; Immunocompromised; Mpox disease; Outbreak.

PubMed Disclaimer

Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: German Ramirez-Olivencia reports administrative support and article publishing charges were provided by Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (10.13039/501100015756SEIMC). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

    1. Petersen E., Kantele A., Koopmans M., Asogun D., Yinka-Ogunleye A., Ihekweazu C., et al. Human monkeypox: Epidemiologic and clinical characteristics, diagnosis, and Prevention. Infect Dis Clin North Am. 2019;33(4):1027–1043. - PMC - PubMed
    1. Jezek Z., Szczeniowski M., Paluku K.M., Mutombo M. Human monkeypox: clinical features of 282 patients. THE JOURNAL OF INFECTIOUS DISEASES. 1987;156 https://academic.oup.com/jid/article/156/2/293/817320 Available from: - PubMed
    1. Bunge E.M., Hoet B., Chen L., Lienert F., Weidenthaler H., Baer L.R., et al. The changing epidemiology of human monkeypox—a potential threat? A systematic review. PLoS Negl Trop Dis [Internet] 2022;16(2):1–20. doi: 10.1371/journal.pntd.0010141. - DOI - PMC - PubMed
    1. Ee S., Yong F., Ng O.T., Jie Z., Ho M., Mak T.M., et al. Imported monkeypox, Singapore. 2020;26(8):1826–1830. - PMC - PubMed
    1. Erez N., Achdout H., Milrot E., Schwartz Y., Wiener-Well Y., Paran N., et al. Diagnosis of imported monkeypox, Israel, 2018. Emerg. Infect. Dis. 2019;25(5):980–983. - PMC - PubMed

LinkOut - more resources