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. 1985 Sep 1;162(3):1015-24.
doi: 10.1084/jem.162.3.1015.

Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes

P G Pelicci, D M Knowles 2nd, R Dalla Favera

Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes

P G Pelicci et al. J Exp Med. .

Abstract

Ig and T beta gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that approximately 10% of the cases tested displayed rearrangements of both Ig and T beta genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.

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References

    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 May;82(10):3460-4 - PubMed
    1. Nature. 1978 Dec 21-28;276(5690):790-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3683-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 May;77(5):2876-80 - PubMed

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