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. 2024 Apr 26;27(6):267.
doi: 10.3892/etm.2024.12555. eCollection 2024 Jun.

Association of IL‑6 and MMP‑3 gene polymorphisms with adolescent idiopathic scoliosis: A systematic review and meta‑analysis

Yue-Peng Wang  1 , Shi-Lei Qin  2 , Su Yang  3 , Yun-Feng Xu  2 , Peng-Fei Han  3 , Ai-Hua Liu  1 , Ke-Dong Hou  1 , Jian-Ping He  1
Affiliations

Association of IL‑6 and MMP‑3 gene polymorphisms with adolescent idiopathic scoliosis: A systematic review and meta‑analysis

Yue-Peng Wang et al. Exp Ther Med. .

Abstract

The pathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear. It has been found that interleukin-6 (IL-6) rs1800795 locus and matrix metalloproteinase-3 (MMP-3) rs3025058 locus gene polymorphisms may be associated with AIS susceptibility, which has been controversial and needs to be further confirmed by updated meta-analysis. The aim of the present study was to investigate the association of MMP-3 rs3025058 and IL-6 rs1800795 single nucleotide polymorphisms (SNPs) with susceptibility to AIS. All relevant articles that met the criteria were retrieved and included, and the publication dates were limited from January 2005 to December 2023. The allele frequencies and different genotype frequencies of IL-6 rs1800795 and MMP-3 rs3025058 loci in each study were extracted and statistically analyzed by ReviewManager 5.4 software, and the odds ratio (OR) and 95% confidence interval (95% CI) of different genetic models were calculated. The results of the meta-analysis showed that there was no significant association between the gene polymorphism of IL-6 rs1800795 locus and the pathogenesis of AIS. The allele 5A and genotype 5A5A of MMP-3 rs3025058 SNP were associated with AIS susceptibility (5A vs. 6A, OR=1.18; 95% CI, 1.04-1.33; 5A5A vs. 6A6A, OR=1.65; 95% CI, 1.23-2.21; and 5A5A vs. 5A6A + 6A6A, OR=1.54; 95% CI, 1.19-1.99). Results of subgroup analysis revealed that the allele 5A and genotype 5A5A of MMP-3 rs3025058 SNP were associated with AIS susceptibility in the Caucasian population, and the susceptibility of AIS was associated with the genotype 5A5A of MMP-3 rs3025058 SNP in an Asian population. There was no significant association between the gene polymorphism of IL-6 rs1800795 locus and the pathogenesis of AIS, while the allele 5A of MMP-3 rs3025058 locus was associated with the susceptibility to AIS, especially in the Caucasian population.

Keywords: IL-6; MMP-3; adolescent idiopathic scoliosis; meta-analysis; single nucleotide polymorphism.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of the literature search.
Figure 2
Figure 2
Forest plot of the association between IL-6 rs1800795 single nucleotide polymorphism and adolescent idiopathic scoliosis risk for the allelic comparison (C vs. G). MH, Mantel-Haenszel; CI, confidence interval.
Figure 3
Figure 3
Forest plot of the association between IL-6 rs1800795 single nucleotide polymorphism and adolescent idiopathic scoliosis risk for the codominance model comparison (CC vs. GG). CI, confidence interval; MH, Mantel-Haenszel.
Figure 4
Figure 4
Forest plot of the association between IL-6 rs1800795 single nucleotide polymorphism and adolescent idiopathic scoliosis risk for the codominance model comparison (CG vs. GG). MH, Mantel-Haenszel; CI, confidence interval.
Figure 5
Figure 5
Forest plot of the association between IL-6 rs1800795 single nucleotide polymorphism and adolescent idiopathic scoliosis risk for the dominant model comparison (CC + CG vs. GG). MH, Mantel-Haenszel; CI, confidence interval.
Figure 6
Figure 6
Forest plot of the association between IL-6 rs1800795 single nucleotide polymorphism and adolescent idiopathic scoliosis risk for the recessive model comparison (CC vs. CG + GG). MH, Mantel-Haenszel; CI, confidence interval.
Figure 7
Figure 7
Forest plot of the association between MMP-3 rs3025058 single nucleotide polymorphism and adolescent idiopathic scoliosis risk for the allelic model comparison (5A vs. 6A). MH, Mantel-Haenszel; CI, confidence interval.
Figure 8
Figure 8
Forest plot of the association between MMP-3 rs3025058 single nucleotide polymorphism and adolescent idiopathic scoliosis risk for the codominance model comparison (5A5A vs. 6A6A). MH, Mantel-Haenszel; CI, confidence interval.
Figure 9
Figure 9
Forest plot of the association between MMP-3 rs3025058 single nucleotide polymorphism and adolescent idiopathic scoliosis risk for the recessive model comparison (5A5A vs. 5A6A + 6A6A). MH, Mantel-Haenszel; CI, confidence interval.
Figure 10
Figure 10
Trim funnel plots of publishing bias. (A) The allelic comparison (C vs. G). (B) The codominance model comparison (CC vs. GG). (C) The codominance model comparison (CG vs. GG). (D) The dominant model comparison (CC + CG vs. GG). (E) The recessive model comparison (CC vs. CG + GG). (F) The allelic model comparison (5A vs. 6A). (G) The codominance model comparison (5A5A vs. 6A6A). (H) The recessive model comparison (5A5A vs. 5A6A + 6A6A).
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