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. 2025 May 1;281(5):787-795.
doi: 10.1097/SLA.0000000000006344. Epub 2024 May 17.

Reducing Chronic Opioid Use: Long-term Impacts of Enhanced Recovery After Mastectomy Protocols

Kristen Jogerst  1   2 , Nikita Gupta  3 , Heidi E Kosiorek  4 , Yeonsoo S Lee  3 , Sami Abujbarah  3 , Patricia Cronin  1 , William Casey  5 , Barbara Pockaj  1
Affiliations

Reducing Chronic Opioid Use: Long-term Impacts of Enhanced Recovery After Mastectomy Protocols

Kristen Jogerst et al. Ann Surg. .

Abstract

Objective: This study investigates Enhanced Recovery After Surgery (ERAS) protocols' impact on long-term opioid and sedative use following mastectomy with or without implant-based breast reconstruction (IBBR).

Background: ERAS protocols for patients undergoing mastectomy with or without IBBR are associated with decreased length of stay, increased rate of same-day discharge, decreased postoperative pain, and decreased postoperative opioid requirements. However, less is known about their effect on opioid and sedative use beyond 90 days after surgery.

Methods: A retrospective review of all patients undergoing mastectomy with or without IBBR at a single institution between January 2013 and December 2019. Mastectomy ERAS protocols were implemented in February 2017, creating 2 groups: pre-ERAS and ERAS. Baseline characteristics and prevalence of chronic opioid and sedative use were compared. Univariable and multivariable logistic regression predicted factors associated with increased odds of chronic opioid and sedative use.

Results: A total of 756 patients were evaluated: 405 pre-ERAS and 351 ERAS. Post-ERAS, chronic opioid use decreased in opioid-naive (40% vs 30%, P =0.024) and opioid-tolerant patients (58% vs 37%, P =0.002), with no increase in chronic sedative use. There were decreased odds of chronic opioid use for all ERAS patients (OR=0.57, 95% CI: 0.42-0.76), and of IBBR patients, those receiving subcutaneous implants (OR=0.31, 95% CI: 0.20-0.48). There was increased chronic opioid-use odds if undergoing bilateral surgery (OR=1.54, 95% CI: 1.14-2.08), 2-stage reconstruction (OR=9.78, 95% CI: 5.94-16.09), and for patients with higher PACU pain scores (OR=1.09, 95% CI: 1.03-1.14) or >150 discharge OMEs (OR=2.63, 95% CI: 1.48-4.68).

Conclusion: ERAS protocols for mastectomy patients with or without IBR are associated with decreases in chronic opioid use, without concomitant increases in chronic sedative use.

Keywords: breast surgery protocols; chronic opioid use; chronic sedative use; postoperative pain; same-day mastectomy.

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Conflict of interest statement

The authors report no conflicts of interest.

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