Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024;30(21):1699-1704.
doi: 10.2174/0113816128296935240502070245.

Protective Effects of the Aqueous Extract of Malva sylvestris Plant against the Lethality and Histopathological Damage in Experimental Envenoming of Hemiscorpius lepturus Venom in Balb/c Mice

Sayyed Matin Ahmadi  1 , Mohammad Yousofpour  2   3 , Mohammad Kamalinejad  4 , Arman Otroshi  5 , Fereshteh Talebpour Amiri  6 , Abbas Alipour  7 , Mohammad Reza Zareinejad  8 , Delavar Shahbazzadeh  8
Affiliations

Protective Effects of the Aqueous Extract of Malva sylvestris Plant against the Lethality and Histopathological Damage in Experimental Envenoming of Hemiscorpius lepturus Venom in Balb/c Mice

Sayyed Matin Ahmadi et al. Curr Pharm Des. 2024.

Abstract

Introduction: Hemiscorpius lepturus envenomation is a serious health problem in the southern provinces of Iran. The antiserum produced in Iran to counteract this scorpion venom is not entirely effective due to the risk of anaphylactic shock and other adverse effects.

Methods: Therefore, more efficient alternatives to treat patients deserve attention, and plants are extensively good candidates to be studied. This study aimed to assess the potential of the aqueous fraction of Malva sylvestris in inhibiting the toxic effects of H. lepturus venom. Injection of sub-lethal dose of H. lepturus venom leads to severe tissue damage in vital organs including the kidney, liver, heart and intestine, after 24 hours.

Results: By injecting 80 mg of the aqueous extract of M. sylvestris into the peritoneum helped treat the damaged tissues caused by H. lepturus venom in mice.

Conclusion: Thus, Malva sylvestris could serve as an alternative treatment for scorpion sting envenomation and may be used as a drug to neutralize relevant toxic effects in patients stung by H. lepturus.

Keywords: Hemiscorpius lepturus; Malva sylvestris (PANIRAK); Persian medicine; acute kidney injury.; drug lead; scorpion envenomation.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Dehghani R.; Kamiabi F.; Mohammadi M.; Scorpionism by Hemiscorpius spp. in Iran: A review. J Venom Anim Toxins Incl Trop Dis 2018,24(1),8 - DOI - PubMed
    1. Dizaji R.; Sharafi A.; Pourahmad J.; Vatanpour S.; Hosseini M.J.; Vatanpour H.; The effects of Hemiscorpius lepturus induced-acute kidney injury on PGC-1α gene expression: From induction to suppression in mice. Toxicon 2020,174,57-63 - DOI - PubMed
    1. Pipelzadeh M.H.; Jalali A.; Taraz M.; Pourabbas R.; Zaremirakabadi A.; An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus. Toxicon 2007,50(7),984-992 - DOI - PubMed
    1. Dehghani R.; Khamechian T.; Vazirianzadeh B.; Vatandoost H.; Moravvej S.; Toxic effects of scorpion, Hemiscorpius lepturus (Hemiscorpiidae) venom on mice. J Anim Plant Sci 2012,22(3),593-596
    1. Valavi E.; Ansari A.M.J.; Hemolytic uremic syndrome following Hemiscorpius lepturus (scorpion) sting. Indian J Nephrol 2008,18(4),166-168 - DOI - PubMed

Supplementary concepts

LinkOut - more resources