The ROMA trial: 7 years of trial activities and the development of the ROMA trial network

doi:10.1093/ejcts/ezae188

Editorial

. 2024 May 3;65(5):ezae188.

doi: 10.1093/ejcts/ezae188.

The ROMA trial: 7 years of trial activities and the development of the ROMA trial network

Mario Gaudino¹, Massimo Lemma², Sigrid Sandner³, Andreas Boening⁴, Lamia Harik¹, Marc Albert⁵, Jose Albors Martin⁶, Jorge Alcocer⁷, John H Alexander⁸, Deepak L Bhatt⁹, Nikolaos Bonaros¹⁰, Michael Borger¹¹, Bernhard C Danner¹², Piroze Davierwala¹³, Marek A Deja¹⁴, Ruggero De Paulis¹⁵, Marcus-Andre Deutsch¹⁶, Marcus Flather¹⁷, Pieter Kappetein¹⁸, Paul Kurlansky¹⁹, Andre Lamy²⁰, Roberto Lorusso²¹, Gopi Chand Mannam²², Mohamed Marzouk²³, Ruth Masterson Creber²⁴, Milan Milojevic^{25

26}, Giuseppe Nasso²⁷, Nirav Patel²⁸, Ivana Petrovic²⁹, Eduard Quintana⁷, Lokeswara Rao Sajja²², Mauro Rinaldi³⁰, Lisa Rong³¹, Igor Rudez³², Marc Ruel³³, Elfriede Ruttmann-Ulmer¹⁰, Pierre Voisine³³, Qiang Zhao³⁴, Zhe Zheng³⁵, Stephen E Fremes³⁶

Affiliations

¹ Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
² Department of Cardiac Surgery, Jilin Heart Hospital, Changchun, China.
³ Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
⁴ Department of Cardiovascular Surgery, University Hospital Giessen, Giessen, Germany.
⁵ Department of Cardiovascular Surgery, Robert-Bosch Hospital, Stuttgart, Germany.
⁶ Department of Cardiac Surgery, Hospital Universitario del Vinalopo, Alicante, Spain.
⁷ Department of Cardiac Surgery, Hospital Clinic de Barcelona, Barcelona, Spain.
⁸ Duke Clinical Research Institute, Division of Cardiology, Duke University, Durham, NC, USA.
⁹ Department of Medicine, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁰ Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
¹¹ Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.
¹² Department of Thoracic and Cardiovascular Surgery, University Hospital of Goettingen, Goettingen, Germany.
¹³ Department of Surgery, Division of Cardiac Surgery, Toronto General Hospital, Toronto, ON, Canada.
¹⁴ Department of Cardiac Surgery, Medical University of Silesia-Katowice, Katowice, Poland.
¹⁵ Department of Cardiac Surgery, European Hospital, Unicamillus University, Rome, Italy.
¹⁶ Department of Thoracic and Cardiovascular Surgery, HDZ NRW, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.
¹⁷ Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
¹⁸ Medtronic Bakken Research Center, Maastricht, Netherlands.
¹⁹ Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA.
²⁰ Department of Surgery, McMaster University, Hamilton, ON, Canada.
²¹ Department of Cardio-Thoracic Surgery, Maastricht University Medical Center and Cardiovascular Research Maastricht, Maastricht, Netherlands.
²² Department of Cardiothoracic Surgery, Star Hospitals, Hyderabad, India.
²³ Department of Cardiovascular Surgery, IUCPQ, Universite Laval, Quebec City, QC, Canada.
²⁴ Columbia University School of Nursing, New York, NY, USA.
²⁵ Department of Cardiac Surgery and Cardiovascular Research, Dedinje Cardiovascular Institute, Belgrade, Serbia.
²⁶ Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, Netherlands.
²⁷ Department of Cardiac Surgery, Anthea Hospital, Bari, Italy.
²⁸ Department of Cardiovascular and Thoracic Surgery, Northwell Health, New Hyde Park, NY, USA.
²⁹ Department of Cardiosurgery, Center of Excellence, Dedinje Cardiovascular Institute, Belgrade, Serbia.
³⁰ Department of Cardiac Surgery, University of Turin, Turin, Italy.
³¹ Department of Anesthesia, Weill Cornell Medicine, New York, NY, USA.
³² Department of Cardiac and Transplant Surgery, Dubrava University Hospital, Zagreb, Croatia.
³³ Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON, Canada.
³⁴ Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³⁵ Department of Cardiac Surgery, Fuwai Hospital, Beijing, China.
³⁶ Division of Cardiac Surgery, Schulich Heart Centre, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

PMID: 38758192
PMCID: PMC11099650
DOI: 10.1093/ejcts/ezae188

Editorial

The ROMA trial: 7 years of trial activities and the development of the ROMA trial network

Mario Gaudino et al. Eur J Cardiothorac Surg. 2024.

. 2024 May 3;65(5):ezae188.

doi: 10.1093/ejcts/ezae188.

Authors

Affiliations

¹ Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
² Department of Cardiac Surgery, Jilin Heart Hospital, Changchun, China.
³ Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
⁴ Department of Cardiovascular Surgery, University Hospital Giessen, Giessen, Germany.
⁵ Department of Cardiovascular Surgery, Robert-Bosch Hospital, Stuttgart, Germany.
⁶ Department of Cardiac Surgery, Hospital Universitario del Vinalopo, Alicante, Spain.
⁷ Department of Cardiac Surgery, Hospital Clinic de Barcelona, Barcelona, Spain.
⁸ Duke Clinical Research Institute, Division of Cardiology, Duke University, Durham, NC, USA.
⁹ Department of Medicine, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁰ Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
¹¹ Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.
¹² Department of Thoracic and Cardiovascular Surgery, University Hospital of Goettingen, Goettingen, Germany.
¹³ Department of Surgery, Division of Cardiac Surgery, Toronto General Hospital, Toronto, ON, Canada.
¹⁴ Department of Cardiac Surgery, Medical University of Silesia-Katowice, Katowice, Poland.
¹⁵ Department of Cardiac Surgery, European Hospital, Unicamillus University, Rome, Italy.
¹⁶ Department of Thoracic and Cardiovascular Surgery, HDZ NRW, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.
¹⁷ Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
¹⁸ Medtronic Bakken Research Center, Maastricht, Netherlands.
¹⁹ Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA.
²⁰ Department of Surgery, McMaster University, Hamilton, ON, Canada.
²¹ Department of Cardio-Thoracic Surgery, Maastricht University Medical Center and Cardiovascular Research Maastricht, Maastricht, Netherlands.
²² Department of Cardiothoracic Surgery, Star Hospitals, Hyderabad, India.
²³ Department of Cardiovascular Surgery, IUCPQ, Universite Laval, Quebec City, QC, Canada.
²⁴ Columbia University School of Nursing, New York, NY, USA.
²⁵ Department of Cardiac Surgery and Cardiovascular Research, Dedinje Cardiovascular Institute, Belgrade, Serbia.
²⁶ Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, Netherlands.
²⁷ Department of Cardiac Surgery, Anthea Hospital, Bari, Italy.
²⁸ Department of Cardiovascular and Thoracic Surgery, Northwell Health, New Hyde Park, NY, USA.
²⁹ Department of Cardiosurgery, Center of Excellence, Dedinje Cardiovascular Institute, Belgrade, Serbia.
³⁰ Department of Cardiac Surgery, University of Turin, Turin, Italy.
³¹ Department of Anesthesia, Weill Cornell Medicine, New York, NY, USA.
³² Department of Cardiac and Transplant Surgery, Dubrava University Hospital, Zagreb, Croatia.
³³ Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON, Canada.
³⁴ Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³⁵ Department of Cardiac Surgery, Fuwai Hospital, Beijing, China.
³⁶ Division of Cardiac Surgery, Schulich Heart Centre, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

PMID: 38758192
PMCID: PMC11099650
DOI: 10.1093/ejcts/ezae188

No abstract available

Keywords: Coronary artery bypass grafting; Multiple arterial grafting; Randomized clinical trials.

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Figures

**Figure 1:**
ROMA cumulative enrollment and the effect of the COVID-19 pandemic (panel). COVID-19: coronavirus disease 2019; ROMA: Randomized Comparison of the Clinical Outcomes of Single versus Multiple Arterial Grafts.

**Figure 2:**
Large contemporary CABG trials. ART: Arterial Revascularization Trial; CORONARY: Coronary Artery Bypass Surgery Off or On Pump Revascularization Study; EXCEL: Evaluation of XIENCE versus Coronary Artery Bypass Graft Surgery for Effectiveness of Left Main Revascularizaton trial; FREEDOM: Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease trial; NOBLE: Nordic Baltic British Left Main Revascularization trial; PREVENT IV: The PRoject of Ex vivo Vein graft ENgineering via Transfection IV trial; ROOBY: Randomized On/Off Bypass trial; ROMA: Randomized Comparison of the Clinical Outcomes of Single versus Multiple Arterial Grafts trial; SYNTAX: Synergy Between PCI with Taxus and Cardiac Surgery trial.

See this image and copyright information in PMC

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References

1. Gaudino M, Alexander JH, Bakaeen FG, Ballman K, Barili F, Calafiore AM. et al. Randomized comparison of the clinical outcome of single versus multiple arterial grafts: the ROMA trial—rationale and study protocol. Eur J Cardiothorac Surg 2017;52:1031–40. - PubMed
1. Taggart DP, Altman DG, Gray AM, Lees B, Gerry S, Benedetto U. et al.; ART Investigators. Randomized trial of bilateral versus single internal-thoracic-artery grafts. N Engl J Med 2016;375:2540–9. - PubMed
1. Gaudino M, Bakaeen F, Benedetto U, Rahouma M, Di Franco A, Tam DY. et al. Use rate and outcome in bilateral internal thoracic artery grafting: insights from a systematic review and meta‐analysis. JAHA 2018;7:e009361. - PMC - PubMed
1. Benedetto U, Raja SG, Albanese A, Amrani M, Biondi-Zoccai G, Frati G.. Searching for the second best graft for coronary artery bypass surgery: a network meta-analysis of randomized controlled trials. Eur J Cardiothorac Surg 2015;47:59–65; discussion 65. - PubMed
1. Persson M, Sartipy U.. Bilateral versus single internal thoracic artery grafts. Curr Cardiol Rep 2018;20:4. - PMC - PubMed

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[1] Gaudino M, Alexander JH, Bakaeen FG, Ballman K, Barili F, Calafiore AM. et al. Randomized comparison of the clinical outcome of single versus multiple arterial grafts: the ROMA trial—rationale and study protocol. Eur J Cardiothorac Surg 2017;52:1031–40. - PubMed

[2] Gaudino M, Alexander JH, Bakaeen FG, Ballman K, Barili F, Calafiore AM. et al. Randomized comparison of the clinical outcome of single versus multiple arterial grafts: the ROMA trial—rationale and study protocol. Eur J Cardiothorac Surg 2017;52:1031–40. - PubMed

[3] Taggart DP, Altman DG, Gray AM, Lees B, Gerry S, Benedetto U. et al.; ART Investigators. Randomized trial of bilateral versus single internal-thoracic-artery grafts. N Engl J Med 2016;375:2540–9. - PubMed

[4] Taggart DP, Altman DG, Gray AM, Lees B, Gerry S, Benedetto U. et al.; ART Investigators. Randomized trial of bilateral versus single internal-thoracic-artery grafts. N Engl J Med 2016;375:2540–9. - PubMed

[5] Gaudino M, Bakaeen F, Benedetto U, Rahouma M, Di Franco A, Tam DY. et al. Use rate and outcome in bilateral internal thoracic artery grafting: insights from a systematic review and meta‐analysis. JAHA 2018;7:e009361. - PMC - PubMed

[6] Gaudino M, Bakaeen F, Benedetto U, Rahouma M, Di Franco A, Tam DY. et al. Use rate and outcome in bilateral internal thoracic artery grafting: insights from a systematic review and meta‐analysis. JAHA 2018;7:e009361. - PMC - PubMed

[7] Benedetto U, Raja SG, Albanese A, Amrani M, Biondi-Zoccai G, Frati G.. Searching for the second best graft for coronary artery bypass surgery: a network meta-analysis of randomized controlled trials. Eur J Cardiothorac Surg 2015;47:59–65; discussion 65. - PubMed

[8] Benedetto U, Raja SG, Albanese A, Amrani M, Biondi-Zoccai G, Frati G.. Searching for the second best graft for coronary artery bypass surgery: a network meta-analysis of randomized controlled trials. Eur J Cardiothorac Surg 2015;47:59–65; discussion 65. - PubMed

[9] Persson M, Sartipy U.. Bilateral versus single internal thoracic artery grafts. Curr Cardiol Rep 2018;20:4. - PMC - PubMed

[10] Persson M, Sartipy U.. Bilateral versus single internal thoracic artery grafts. Curr Cardiol Rep 2018;20:4. - PMC - PubMed

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The ROMA trial: 7 years of trial activities and the development of the ROMA trial network

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The ROMA trial: 7 years of trial activities and the development of the ROMA trial network

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