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Randomized Controlled Trial
. 2024 May 17;103(20):e38235.
doi: 10.1097/MD.0000000000038235.

Effects of preoperative inhaled budesonide combined with intravenous dexamethasone on postoperative sore throat in patients who underwent thyroidectomy: A randomized controlled trial

Ping-Ping Chen  1 , Xing Zhang  2 , Hui Ye  3 , Dan Chen  1
Affiliations
Randomized Controlled Trial

Effects of preoperative inhaled budesonide combined with intravenous dexamethasone on postoperative sore throat in patients who underwent thyroidectomy: A randomized controlled trial

Ping-Ping Chen et al. Medicine (Baltimore). .

Abstract

Background: This randomized controlled trial aimed to evaluate the efficacy of preoperative inhaled budesonide combined with intravenous dexamethasone on postoperative sore throat (POST) after general anesthesia in patients who underwent thyroidectomy.

Methods: Patients who underwent elective thyroidectomy were randomly divided into the intravenous dexamethasone group (group A) and budesonide inhalation combined with intravenous dexamethasone group (group B). All patients underwent general anesthesia. The incidence and severity of POST, hoarseness, and cough at 1, 6, 12, and 24 hours after surgery were evaluated and compared between the 2 groups.

Results: There were 48 and 49 patients in groups A and B, respectively. The incidence of POST was significantly lower at 6, 12, and 24 hours in group B than that in group A (P < .05). In addition, group B had a significantly lower incidence of coughing at 24 hours (P = .047). Compared with group A, the severity of POST was significantly lower at 6 (P = .027), 12 (P = .004), and 24 (P = .005) hours at rest, and at 6 (P = .002), 12 (P = .038), and 24 (P = .015) hours during swallowing in group B. The incidence and severity of hoarseness were comparable at each time-point between the 2 groups (P > .05).

Conclusion: Preoperative inhaled budesonide combined with intravenous dexamethasone reduced the incidence and severity of POST at 6, 12, and 24 hours after extubation compared with intravenous dexamethasone alone in patients who underwent thyroidectomy. Additionally, this combination decreased the incidence of postoperative coughing at 24 hours.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flowchart of the study.
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References

    1. Jiang J, Wang Z, Xu Q, Chen Q, Lu W. Development of a nomogram for prediction of postoperative sore throat in patients under general anaesthesia: a single-centre, prospective, observational study. BMJ Open. 2022;12:e059084. - PMC - PubMed
    1. Jau PY, Chang SC. The effectiveness of acupuncture point stimulation for the prevention of postoperative sore throat: a meta-analysis. Medicine (Baltimore). 2022;101:e29653. - PMC - PubMed
    1. Mitobe Y, Yamaguchi Y, Baba Y, et al. . A literature review of factors related to postoperative sore throat. J Clin Med Res. 2022;14:88–94. - PMC - PubMed
    1. Zheng ZP, Tang SL, Fu SL, et al. . Identifying the risk factors for postoperative sore throat after endotracheal intubation for oral and maxillofacial surgery. Ther Clin Risk Manag. 2023;19:163–70. - PMC - PubMed
    1. Kuriyama A, Maeda H, Sun R. Aerosolized corticosteroids to prevent postoperative sore throat in adults: a systematic review and meta-analysis. Acta Anaesthesiol Scand. 2019;63:282–91. - PubMed

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