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Review
. 2024 Sep:513:3-11.
doi: 10.1016/j.ydbio.2024.05.010. Epub 2024 May 15.

The development of hair follicles and nail

Soung-Hoon Lee  1 , Sarah Platt  2 , Chae Ho Lim  1 , Mayumi Ito  1 , Peggy Myung  3
Affiliations
Review

The development of hair follicles and nail

Soung-Hoon Lee et al. Dev Biol. 2024 Sep.

Abstract

The hair follicle and nail unit develop and regenerate through epithelial-mesenchymal interactions. Here, we review some of the key signals and molecular interactions that regulate mammalian hair follicle and nail formation during embryonic development and how these interactions are reutilized to promote their regeneration during adult homeostasis and in response to skin wounding. Finally, we highlight the role of some of these signals in mediating human hair follicle and nail conditions.

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Figures

Fig. 1.
Fig. 1.. Morphological changes of HF during hair cycle and development.
(a) Repetitive hair cycle is achieved by coordinated regulation of a variety of cell cypes in HF such as EpSCs, McSCs, DP cells, and dermal sheath cells. (b) Reciprocal communications between epidermal and dermal cells lead to HF development. HF EpSCs, hair follicle epithelial stem cells; TACs, transit-amplifying cells; McSCs, melanocyte stem cells; MCs, melanocytes; SG, sebacious gland; sHG, secondary hair germ; DP, dermal papilla; HS, hair shaft; IRS, inner root sheath; ORS, outer root sheath; DC, dermal condensates.
Fig. 2.
Fig. 2.. Spatio-tempral regulation of Wnt and SHH pathways during DC/DP fomration in embryonic skin (a) and skin wounds (b).
It remains to be determined whether Wnt and SHH pathways cooperate with each other to develop neogenic HFs in skin wounds as those pathways do during HF development. DC, dermal condensates DP; dermal papilla.
Fig. 3.
Fig. 3.. Anatomy of mouse digit tip.
Various signaling pathways such as Wnt and BMP regulate nail development.
See this image and copyright information in PMC

References

    1. Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, Belguith H, de Mazancourt P, Megarbane A, 2007. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. Am. J. Hum. Genet 81, 821–828. - PMC - PubMed
    1. Adamska M, Billi AC, Cheek S, Meisler MH, 2005. Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb. Dev. Dyn 233, 368–372. - PubMed
    1. Alkhowailed MS, Otayf M, Albasseet A, Almousa A, Alajlan Z, Altalhab S, 2021. Clinical Approach to Linear Hyperpigmentation: A Review Article. Clin. Cosmet. Investig. Dermatol 14, 23–35. - PMC - PubMed
    1. Alvarez-Medina R, Cayuso J, Okubo T, Takada S, Martí E, 2008. Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development 135, 237–247. - PubMed
    1. Andl T, Reddy ST, Gaddapara T, Millar SE, 2002. WNT signals are required for the initiation of hair follicle development. Dev. Cell 2, 643–653. - PubMed

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