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Comment
. 2024 Oct;21(10):578-579.
doi: 10.1038/s41585-024-00896-6.

Overall survival with adjuvant pembrolizumab in renal cell carcinoma - the shock of the lightning

Francesco Massari #  1   2 , Matteo Rosellini #  3   4 , Veronica Mollica  3
Affiliations
Comment

Overall survival with adjuvant pembrolizumab in renal cell carcinoma - the shock of the lightning

Francesco Massari et al. Nat Rev Urol. 2024 Oct.
No abstract available

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Comment on

  • Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma.
    Choueiri TK, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Chang YH, Lee JL, Sarwar N, Haas NB, Gurney H, Sawrycki P, Mahave M, Gross-Goupil M, Zhang T, Burke JM, Doshi G, Melichar B, Kopyltsov E, Alva A, Oudard S, Topart D, Hammers H, Kitamura H, McDermott DF, Silva A, Winquist E, Cornell J, Elfiky A, Burgents JE, Perini RF, Powles T; KEYNOTE-564 Investigators. Choueiri TK, et al. N Engl J Med. 2024 Apr 18;390(15):1359-1371. doi: 10.1056/NEJMoa2312695. N Engl J Med. 2024. PMID: 38631003 Clinical Trial.

References

    1. Massari, F. et al. Adjuvant treatment for resected renal cell carcinoma: are all strategies equally negative? Potential implications for trial design with targeted agents. Clin. Genitourin. Cancer 11, 471–476 (2013). - DOI - PubMed
    1. Ravaud, A. et al. Adjuvant sunitinib in high-risk renal-cell carcinoma after nephrectomy. N. Engl. J. Med. 375, 2246–2254 (2016). - DOI - PubMed
    1. Choueiri, T. K. et al. Overall survival with adjuvant pembrolizumab in renal-cell carcinoma. N. Engl. J. Med. 390, 1359–1371 (2024). - DOI - PubMed
    1. Mollica, V. & Massari, F. Adjuvant treatment in renal cell carcinoma: a never-ending story? Lancet 403, 433–434 (2024). - DOI - PubMed
    1. Rosellini, M. et al. Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma. Nat. Rev. Urol. 20, 133–157 (2023). - DOI - PubMed

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