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. 1985 Sep;28(9):999-1007.
doi: 10.1002/art.1780280907.

Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives

D A Isenberg, Y Shoenfeld, M Walport, C Mackworth-Young, C Dudeney, A Todd-Pokropek, S Brill, A Weinberger, J Pinkas

Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives

D A Isenberg et al. Arthritis Rheum. 1985 Sep.

Abstract

Two common cross-reacting anti-DNA antibody idiotypes designated 16/6 and 32/15, previously identified in the serum of patients who have systemic lupus erythematosus, were found in 24% and 7%, respectively, of 147 first-degree relatives. These findings imply that high-frequency germ-line genes exist among lupus relatives, as well as patients. These dominant or public anti-DNA antibody idiotypes are not likely to be pathogenic factors, but are probably a genetically associated phenomenon.

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