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Review
. 2024 Oct;49(10):3559-3573.
doi: 10.1007/s00261-024-04358-w. Epub 2024 May 18.

Early detection of pancreatic cancer in the era of precision medicine

Taha M Ahmed  1 , Satomi Kawamoto  1 , Felipe Lopez-Ramirez  1 , Mohammad Yasrab  1 , Ralph H Hruban  2 , Elliot K Fishman  1 , Linda C Chu  3
Affiliations
Review

Early detection of pancreatic cancer in the era of precision medicine

Taha M Ahmed et al. Abdom Radiol (NY). 2024 Oct.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality and it is often diagnosed at advanced stages due to non-specific clinical presentation. Disease detection at localized disease stage followed by surgical resection remains the only potentially curative treatment. In this era of precision medicine, a multifaceted approach to early detection of PDAC includes targeted screening in high-risk populations, serum biomarkers and "liquid biopsies", and artificial intelligence augmented tumor detection from radiologic examinations. In this review, we will review these emerging techniques in the early detection of PDAC.

Keywords: Artificial intelligence; CT; Cancer screening; Liquid biopsy; MRI; Pancreatic ductal adenocarcinoma.

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References

    1. Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA: A Cancer Journal for Clinicians. 2024;74(1):12–49. https://doi.org/10.3322/caac.21820 .
    1. Rahib L, Wehner MR, Matrisian LM, Nead KT. Estimated Projection of US Cancer Incidence and Death to 2040. JAMA Network Open. 2021;4(4):e214708. doi: https://doi.org/10.1001/jamanetworkopen.2021.4708 . - DOI - PubMed - PMC
    1. Cancer of the Pancreas - Cancer Stat Facts. SEER. https://seer.cancer.gov/statfacts/html/pancreas.html . Accessed September 30, 2023.
    1. Hackert T, Klaiber U, Pausch T, Mihaljevic AL, Büchler MW. Fifty Years of Surgery for Pancreatic Cancer. Pancreas. 2020;49(8):1005–1013. doi: https://doi.org/10.1097/MPA.0000000000001634 . - DOI - PubMed
    1. Takikawa T, Kikuta K, Hamada S, et al. Clinical features and prognostic impact of asymptomatic pancreatic cancer. Sci Rep. 2022;12:4262. doi: https://doi.org/10.1038/s41598-022-08083-6 . - DOI - PubMed - PMC

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