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Review
. 2024 May 18;41(6):159.
doi: 10.1007/s12032-024-02402-9.

Role of m6A modifications in immune evasion and immunotherapy

Chunyu Wu  1   2 , Lvyuan Li  2 , Qiling Tang  2 , Qianjin Liao  1 , Pan Chen  1 , Can Guo  1 , Zhaoyang Zeng  1   2 , Wei Xiong  3   4
Affiliations
Review

Role of m6A modifications in immune evasion and immunotherapy

Chunyu Wu et al. Med Oncol. .

Abstract

RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N6-methyladenosine (m6A) modification is the most prevalent RNA modification, which can affect the expression of RNA by methylating adenylate at the sixth N position to regulate the occurrence and development of tumors. Dysregulation of m6A affects the activation of cancer-promoting pathways, destroys immune cell function, maintains immunosuppressive microenvironment, and promotes tumor cell growth. In this review, we delve into the latest insights into how abnormalities in m6A modification in both tumor and immune cells orchestrate immune evasion through the activation of signaling pathways. Furthermore, we explore how dysregulated m6A modification in tumor cells influences immune cells, thereby regulating tumor immune evasion via interactions within the tumor microenvironment (TME). Lastly, we highlight recent discoveries regarding specific inhibitors of m6A modulators and the encapsulation of m6A-targeting nanomaterials for cancer therapy, discussing their potential applications in immunotherapy.

Keywords: Immune evasion; Immunotherapy; N6-methyladenosine; Signaling pathways.

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References

    1. An Y, Duan H. The role of m6A RNA methylation in cancer metabolism. Mol Cancer. 2022;21(1):14. - PubMed - PMC - DOI
    1. Wiener D, Schwartz S. The epitranscriptome beyond m(6)A. Nat Rev Genet. 2021;22(2):119–31. - PubMed - DOI
    1. Dai D, Wang H, Zhu L, Jin H, Wang X. N6-methyladenosine links RNA metabolism to cancer progression. Cell Death Dis. 2018;9(2):124. - PubMed - PMC - DOI
    1. Xiao S, Cao S, Huang Q, Xia L, Deng M, Yang M, et al. The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nat Cell Biol. 2019;21(5):651–61. - PubMed - DOI
    1. Zhao W, Qi X, Liu L, Ma S, Liu J, Wu J. Epigenetic regulation of m(6)A modifications in human cancer. Mol Ther Nucleic Acids. 2020;19:405–12. - PubMed - DOI

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