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. 2024 Jul;13(7):1833-1839.
doi: 10.1007/s40123-024-00965-4. Epub 2024 May 18.

Sustained Release Therapies with the Prostaglandin Analogues Intracameral Implants

Abdelrahman M Elhusseiny  1   2 , Ahmad A Aref  3
Affiliations

Sustained Release Therapies with the Prostaglandin Analogues Intracameral Implants

Abdelrahman M Elhusseiny et al. Ophthalmol Ther. 2024 Jul.

Abstract

The travoprost intracameral implant was recently approved by the US Food and Drug Administration for sustained release medical treatment of open-angle glaucoma in the USA. The approval represents a substantial and progressive step forward in the area of sustained-release glaucoma therapy. Topical intraocular pressure-lowering medications for the treatment of glaucoma are faced with a host of challenges for long-term and usually lifelong care. A changing paradigm in glaucoma management involves first-line interventions with laser modalities, micro-invasive surgeries, and sustained-release treatment platforms. Future needs in the area of sustained-release therapy include a non-prostaglandin drug delivery platform and longer-term treatments that do not require surgical reintervention.

Keywords: Drug delivery; Glaucoma; IOP; Implant; Intraocular; Sustained release; Travoprost.

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Conflict of interest statement

Ahmed A. Aref consults for Alcon, New World Medical, Nova Eye Medical, and Dompe. Ahmed A. Aref receives research funding from Abbvie and travel support from Oculus Surgical. Ahmed A. Aref is an Advisory Board member of Ophthalmology and Therapy. Ahmed A. Aref was not involved in the selection of peer reviewers for the manuscript nor any subsequent editorial decisions. Abdelrahman M. Elhusseiny has nothing to disclose.

Figures

Fig. 1
Fig. 1
Design of the travoprost intracameral implant (iDose® TR). Printed with permission from Glaukos Corporation
See this image and copyright information in PMC

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