WFUMB Guideline/Guidance on Liver Multiparametric Ultrasound: Part 1. Update to 2018 Guidelines on Liver Ultrasound Elastography

Giovanna Ferraioli¹, Richard Gary Barr², Annalisa Berzigotti³, Ioan Sporea⁴, Vincent Wai-Sun Wong⁵, Thomas Reiberger⁶, Thomas Karlas⁷, Maja Thiele⁸, Ana Carolina Cardoso⁹, Oyekoya Taiwo Ayonrinde¹⁰, Laurent Castera¹¹, Christoph Frank Dietrich¹², Hiroko Iijima¹³, Dong Ho Lee¹⁴, William Kemp¹⁵, Claudia P Oliveira¹⁶, Shiv Kumar Sarin¹⁷

Affiliations

¹ Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. Electronic address: giovanna.ferraioli@unipv.it.
² Department of Radiology, Northeastern Ohio Medical University, Rootstown, Ohio, USA; Southwoods Imaging, Youngstown, Ohio, USA.
³ Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁴ Division of Gastroenterology and Hepatology, Department of Internal Medicine II, Center for Advanced Research in Gastroenterology and Hepatology, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.
⁵ Medical Data Analytics Centre, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China.
⁶ Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria; Christian-Doppler Laboratory for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.
⁷ Division of Gastroenterology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
⁸ Center for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark; Department for Clinical Research, University of Southern Denmark, Odense, Denmark.
⁹ Hepatology Division, School of Medicine, Federal University of Rio de Janeiro, Clementino, Fraga Filho Hospital, Rua Prof. Rodolpho Paulo Rocco, Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
¹⁰ Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia; Medical School, University of Western Australia, Crawley, Western Australia, Australia; Curtin Medical School, Curtin University, Kent Street, Bentley, Western Australia, Australia.
¹¹ Université Paris-Cité, Inserm UMR1149, Centre de Recherche sur l'Inflammation, Paris, France; Service d'Hépatologie, Hôpital Beaujon, Assistance-Publique Hôpitaux de Paris, Clichy, France.
¹² Department Allgemeine Innere Medizin (DAIM), Kliniken Hirslanden Beau Site, Salem and Permancence, Bern, Switzerland.
¹³ Division of Hepatobiliary and Pancreatic Disease, Department of Gastroenterology, Hyogo Medical University, Nishinomiya, Hyogo, Japan; Ultrasound Imaging Center, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
¹⁴ Department of Radiology, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Republic of Korea.
¹⁵ Department of Gastroenterology, Alfred Hospital, Melbourne, Australia; Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia.
¹⁶ Gastroenterology Department, Laboratório de Investigação (LIM07), Hospital das Clínicas de São Paulo, HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
¹⁷ Department of Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.

PMID: 38762390
DOI: 10.1016/j.ultrasmedbio.2024.03.013

Free article

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WFUMB Guideline/Guidance on Liver Multiparametric Ultrasound: Part 1. Update to 2018 Guidelines on Liver Ultrasound Elastography

Giovanna Ferraioli et al. Ultrasound Med Biol. 2024 Aug.

Free article

. 2024 Aug;50(8):1071-1087.

doi: 10.1016/j.ultrasmedbio.2024.03.013. Epub 2024 May 17.

Authors

Affiliations

¹ Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. Electronic address: giovanna.ferraioli@unipv.it.
² Department of Radiology, Northeastern Ohio Medical University, Rootstown, Ohio, USA; Southwoods Imaging, Youngstown, Ohio, USA.
³ Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁴ Division of Gastroenterology and Hepatology, Department of Internal Medicine II, Center for Advanced Research in Gastroenterology and Hepatology, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.
⁵ Medical Data Analytics Centre, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China.
⁶ Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria; Christian-Doppler Laboratory for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.
⁷ Division of Gastroenterology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
⁸ Center for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark; Department for Clinical Research, University of Southern Denmark, Odense, Denmark.
⁹ Hepatology Division, School of Medicine, Federal University of Rio de Janeiro, Clementino, Fraga Filho Hospital, Rua Prof. Rodolpho Paulo Rocco, Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
¹⁰ Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia; Medical School, University of Western Australia, Crawley, Western Australia, Australia; Curtin Medical School, Curtin University, Kent Street, Bentley, Western Australia, Australia.
¹¹ Université Paris-Cité, Inserm UMR1149, Centre de Recherche sur l'Inflammation, Paris, France; Service d'Hépatologie, Hôpital Beaujon, Assistance-Publique Hôpitaux de Paris, Clichy, France.
¹² Department Allgemeine Innere Medizin (DAIM), Kliniken Hirslanden Beau Site, Salem and Permancence, Bern, Switzerland.
¹³ Division of Hepatobiliary and Pancreatic Disease, Department of Gastroenterology, Hyogo Medical University, Nishinomiya, Hyogo, Japan; Ultrasound Imaging Center, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
¹⁴ Department of Radiology, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Republic of Korea.
¹⁵ Department of Gastroenterology, Alfred Hospital, Melbourne, Australia; Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia.
¹⁶ Gastroenterology Department, Laboratório de Investigação (LIM07), Hospital das Clínicas de São Paulo, HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
¹⁷ Department of Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.

PMID: 38762390
DOI: 10.1016/j.ultrasmedbio.2024.03.013

Abstract

The World Federation for Ultrasound in Medicine and Biology (WFUMB) endorsed the development of this document on multiparametric ultrasound. Part 1 is an update to the WFUMB Liver Elastography Guidelines Update released in 2018 and provides new evidence on the role of ultrasound elastography in chronic liver disease. The recommendations in this update were made and graded using the Oxford classification, including level of evidence (LoE), grade of recommendation (GoR) and proportion of agreement (Oxford Centre for Evidence-Based Medicine [OCEBM] 2009). The guidelines are clinically oriented, and the role of shear wave elastography in both fibrosis staging and prognostication in different etiologies of liver disease is discussed, highlighting advantages and limitations. A comprehensive section is devoted to the assessment of portal hypertension, with specific recommendations for the interpretation of liver and spleen stiffness measurements in this setting.

Keywords: Acoustic radiation force impulse; Alcohol-related liver disease; Cirrhosis; Metabolic dysfunction-associated steatotic liver disease; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Pediatrics; Portal hypertension; Shear wave elastography; Vibration-controlled transient elastography.

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Conflict of interest statement

Conflict of interest G.F. has received a speaker honorarium from Canon Medical Systems, Fujifilm Healthcare, Mindray Medical Imaging, Philips Ultrasound and Siemens Healthineers. She has served on advisory boards for Philips Healthcare and Siemens Healthineers, and her university has received ultrasound equipment grants and unrestricted research grants from Canon Medical Systems, Esaote SpA, Fujifilm Medical Systems and Philips Ultrasound. She receives royalties from Elsevier. R.G.B. has received a speaker honorarium from Canon Medical systems, Philips Ultrasound, Siemens Healthineers, Mindray, Samsung Ultrasound and Hologic Ultrasound. He has received research grants from Philips Ultrasound, Canon Ultrasound, Canon MRI, Samsung, Siemens Healthineers, Hologic and Mindray, and equipment grants from Canon Medical Systems, Philips Ultrasound, Mindray, Samsung Ultrasound and Siemens Healthineers. He is on the advisory board of Lantheus Medical. He receives royalties from Thieme and Elsevier. A.B. is consultant for Boehringer–Ingelheim and has received speaker honoraria from GE Healthcare and Hologic Ultrasound. She has received research ultrasound equipment support from GE Healthcare. I.S. has received speaker fees from Siemens Healthineers, General Electric, Samsung Ultrasound and Canon Medical Systems. V.W.S.W. served as a consultant or advisory board member for AbbVie, Boehringer Ingelheim, Echosens, Gilead Sciences, Intercept, Inventiva, Novo Nordisk, Pfizer, Sagimet Biosciences, TARGET PharmaSolutions and Visirna, and as a speaker for Abbott, AbbVie, Gilead Sciences, Novo Nordisk and Unilab. He has received a research grant from Gilead Sciences and is a co-founder of Illuminatio Medical Technology. T.R. received grant support from Abbvie, Boehringer Ingelheim, Gilead, Intercept/Advanz Pharma, MSD, Myr Pharmaceuticals, Philips Healthcare, Pliant, Siemens and W. L. Gore & Associates; speaking honoraria from Abbvie, Gilead, Intercept/Advanz Pharma, Roche, MSD and W. L. Gore & Associates; a consulting/advisory board fee from Abbvie, Astra Zeneca, Bayer, Boehringer Ingelheim, Gilead, Intercept/Advanz Pharma, MSD, Resolution Therapeutics and Siemens; and travel support from Abbvie, Boehringer Ingelheim, Dr. Falk Pharma, Gilead and Roche. T.K. has received speaker honoraria from Echosens, Falk Foundation and Jazz Pharmaceuticals, and has served on advisory boards for Echosens and his university has received ultrasound equipment and unrestricted research grants from Canon Medical Systems and Echosens. M.T. has received a speaker honorarium from Siemens Healthcare, Echosens, Norgine, Madrigal, Takeda and Tillotts Pharma and an advisory fee from Boehringer Ingelheim, AstraZeneca and GSK; she is a co-founder and board member of Evido and is a board member for Alcohol & Society (non-governmental organization). ACC has received speaker honorarium from Novo Nordisk. O.T.A. has served as a consultant or adviser to Novo Nordisk, Resonance Health, Norgine and Sun Pharma; he has received research ultrasound equipment support from Canon Medical Systems. L.C. has received consulting fees from Boston Pharmaceutical, Echosens, Gilead, GSK, Madrigal, MSD, Novo Nordisk, Pfizer, Sagimet and Siemens Healthineers, and speaker fees from Echosens, Gilead, Inventiva, Madrigal and Novo Nordisk. C.F.D. has received a speaker honorarium from AbbVie, Bracco, Falk Foundation, Fujifilm Healthcare, GE Healthcare, Janssen, Mindray Medical Imaging, Olympus, Pentax, Siemens Healthcare and Sonoscape. H.I. has received research grants from Canon Medical Systems and GE Healthcare and research ultrasound equipment support from Canon Medical Systems. D.H.L. has received research grants and a speaker honorarium from Canon Medical Systems. W.K. has received a speaker honorarium from Novo Nordisk, Eaisi and Roche. C.P.O. has been a consultant or participant in clinical trials for NovoNordisk, Pfizer, Inventiva, Astra-Zeneca and Boehringer Ingelheim. S.K.S. declares no conflicts of interest.

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WFUMB Guideline/Guidance on Liver Multiparametric Ultrasound: Part 1. Update to 2018 Guidelines on Liver Ultrasound Elastography

Affiliations

WFUMB Guideline/Guidance on Liver Multiparametric Ultrasound: Part 1. Update to 2018 Guidelines on Liver Ultrasound Elastography

Authors

Affiliations

Abstract

Conflict of interest statement

References

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MeSH terms

LinkOut - more resources

Full Text Sources

Medical