doi: 10.1016/0014-5793(85)81028-0.
Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+
- PMID: 3876242
- DOI: 10.1016/0014-5793(85)81028-0
Item in Clipboard
Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+
FEBS Lett.
.
Free article
Abstract
[3H]MPP+ had lower Km and higher Vmax values for its accumulation in rat brain synaptosomes than did [3H]MPTP. The kinetic parameters favored the uptake of [3H]MPP+ in the striatum to that in hypothalamus, whereas they were equally favorable for the uptake of [3H]MPTP in both regions. Hypothalamic uptake of [3H]MPTP and [3H]MPP+ was inhibited by desipramine, imipramine, norepinephrine, and serotonin. Striatal uptake of [3H]MPP+ and [3H]MPTP was blocked by nomifensine and dopamine. These results support the concept that MPTP accumulates in serotonergic neurons where it is oxidized by monoamine oxidase B to MPP+, which is released and then is selectively accumulated in dopaminergic neurons via the dopamine uptake system.
Similar articles
-
Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes.Biochem Biophys Res Commun. 1985 May 16;128(3):1228-32. doi: 10.1016/0006-291x(85)91071-x. Biochem Biophys Res Commun. 1985. PMID: 3873939
-
Kinetics of [3H]MPP+ uptake in dopaminergic neurons of mouse: regional effects of MPTP neurotoxicity.Eur J Pharmacol. 1986 Jul 31;126(3):337-9. doi: 10.1016/0014-2999(86)90069-5. Eur J Pharmacol. 1986. PMID: 3489627
-
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.Proc Natl Acad Sci U S A. 1985 Apr;82(7):2173-7. doi: 10.1073/pnas.82.7.2173. Proc Natl Acad Sci U S A. 1985. PMID: 3872460 Free PMC article.
-
Processing of MPTP by monoamine oxidases: implications for molecular toxicology.J Neural Transm Suppl. 1987;23:73-89. doi: 10.1007/978-3-7091-8901-6_5. J Neural Transm Suppl. 1987. PMID: 3295117 Review.
-
Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Toxicol Lett. 1989 Aug;48(2):121-49. doi: 10.1016/0378-4274(89)90168-9. Toxicol Lett. 1989. PMID: 2672418 Review.
Cited by
-
The hypothalamus in MPTP-induced parkinsonism.Ital J Neurol Sci. 1990 Aug;11(4):367-72. doi: 10.1007/BF02335939. Ital J Neurol Sci. 1990. PMID: 2246119 Review.
-
Attenuation of MPTP-induced dopaminergic neurotoxicity by a serotonin uptake blocker.J Neural Transm. 1988;71(2):85-90. doi: 10.1007/BF01245250. J Neural Transm. 1988. PMID: 3258013
-
Effects of sibutramine on the central dopaminergic system in rodents.Neurotox Res. 2001 Jul;3(3):235-47. doi: 10.1007/BF03033262. Neurotox Res. 2001. PMID: 15111248
-
Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective.Animal Model Exp Med. 2022 Feb;5(1):27-37. doi: 10.1002/ame2.12209. Epub 2022 Jan 27. Animal Model Exp Med. 2022. PMID: 35229999 Free PMC article. Review.
-
Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.Cells. 2021 Mar 16;10(3):656. doi: 10.3390/cells10030656. Cells. 2021. PMID: 33809527 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
