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Meta-Analysis
. 2024 May 18;24(1):173.
doi: 10.1186/s12876-024-03264-1.

Medical radiation exposure in inflammatory bowel disease: an updated meta-analysis

Chao Lu  1 , Xin Yao  1 , Mosang Yu  1 , Xinjue He  2
Affiliations
Meta-Analysis

Medical radiation exposure in inflammatory bowel disease: an updated meta-analysis

Chao Lu et al. BMC Gastroenterol. .

Abstract

Background: There have been previous studies and earlier systematic review on the relationship between inflammatory bowel disease (IBD) and radiation exposure. With the diversification of current test methods, this study intended to conduct a meta-analysis to evaluate the IBD radiation exposure in recent years.

Methods: Three databases (PUBMED, EMBASE, and MEDICINE) for relevant literature up to May 1, 2023 were searched. The statistical data meeting requirements were collated and extracted.

Results: 20 papers were enrolled. The overall high radiation exposure rate was 15% (95% CI = [12%, 19%]) for CD and 5% (95% CI = [3%, 7%]) for UC. The pooled result found that high radiation exposure rate was 3.44 times higher in CD than in UC (OR = 3.44, 95% CI = [2.35, 5.02]). Moreover, the average radiation exposure level in CD was 12.77 mSv higher than that in UC (WMD = 12.77, 95% CI = [9.93, 15.62] mSv). Furthermore, radiation exposure level of CD after 2012 was higher than those before 2012 (26.42 ± 39.61vs. 23.76 ± 38.46 mSv, P = 0.016), while UC did not show similar result (11.99 ± 27.66 vs. 10.01 ± 30.76 mSv, P = 0.1). Through subgroup analysis, it was found that disease duration (WMD = 2.75, 95% CI = [0.10, 5.40] mSv), complications (OR = 5.09, 95% CI = [1.50, 17.29]), and surgical history (OR = 5.46, 95% CI = [1.51, 19.69]) significantly increased the proportion of high radiation exposure.

Conclusion: This study found that radiation exposure level of IBD patients was high, which revealed the radiation risk in the process of diagnosis and treatment of IBD patients. In the future, longer follow-up and prospective studies are needed to reveal the relationship between high radiation exposure and solid tumorigenesis.

Keywords: Crohn’s disease; Inflammatory bowel disease; Radiation exposure; Ulcerative colitis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of articles selected
Fig. 2
Fig. 2
Forest plot showed event rate defined as proportion of patients exposed to high diagnostic medical radiation exposure ≥ 50 mSv in CD and UC patients
Fig. 3
Fig. 3
Forest plot showed the difference between radiation exposure level and high radiation exposure odds ratios between CD and UC
Fig. 4
Fig. 4
Forest plot showed odds ratio of risk factors of high radiation exposure grouped according to exposure
See this image and copyright information in PMC

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