Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Sep;56(1):1-7.

Role of T cells in preventing transmission of rodent malaria

P G Harte, N C Rogers, G A Targett

Role of T cells in preventing transmission of rodent malaria

P G Harte et al. Immunology. 1985 Sep.

Abstract

Transmission blocking immunity induced by microgamete vaccination is fully effective for at least 12 months. Passive transfer of immune T cells reduced transmission of a subsequent infection by 95%, the effect being partly due to a significant reduction in numbers of circulating gametocytes during the infection. This immunity was apparently independent of specific antibody, though these were produced within a few days after challenge infection and was mediated by a T cell of the GK1.5+, Ly 2.2 phenotype. Immune serum and immune T cells, administered together, showed a strong additive effect and blocked transmission completely.

PubMed Disclaimer

References

    1. J Immunol. 1977 Feb;118(2):478-84 - PubMed
    1. Infect Immun. 1977 Aug;17(2):430-8 - PubMed
    1. Nature. 1979 Feb 1;277(5695):389-91 - PubMed
    1. Am J Hyg. 1952 Mar;55(2):276-90 - PubMed
    1. Bull World Health Organ. 1971;45(4):524-9 - PubMed

Publication types

Substances

LinkOut - more resources