Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Apr 15;14(2):116-120.
doi: 10.62347/FXLN8938. eCollection 2024.

Suspected colchicine-induced late myocardial rupture occurring after the late presentation of acute inferior ST-elevation myocardial infarction

Abdullah Mohamed Niyas  1   2 , Fathima Haseefa  1 , Jordy Charles Cox  3 , Mohammad Reza Movahed  1   3   4
Affiliations
Case Reports

Suspected colchicine-induced late myocardial rupture occurring after the late presentation of acute inferior ST-elevation myocardial infarction

Abdullah Mohamed Niyas et al. Am J Cardiovasc Dis. .

Abstract

Colchicine is one of the established drugs of choice for post-myocardial infarction (MI) induced pericarditis, given its anti-inflammatory properties. Recently, colchicine received FDA approval for secondary prevention of atherosclerotic cardiovascular disease, which leads to concerns regarding its anti-healing effects on myocardial tissue post-infarction. We present a case of a suspected colchicine-induced myocardial rupture in an elderly male, who presented with a syncopal episode while on colchicine three weeks after the late presentation of infero-posterior ST-elevation myocardial infarction.

Keywords: Colchicine; STEMI; free wall rupture; myocardial infarction; myocardial rupture.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Electrocardiogram on presentation showing completed inferior myocardial infarction.
Figure 2
Figure 2
Echocardiogram showing loculated effusion near inferior wall with no color flow detection from left ventricle.
Figure 3
Figure 3
MRI demonstrating free wall perforation (arrow).
Figure 4
Figure 4
Surgical repair of ruptured myocardium (arrow).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Meyer-Lindemann U, Mauersberger C, Schmidt AC, Moggio A, Hinterdobler J, Li X, Khangholi D, Hettwer J, Gräßer C, Dutsch A, Schunkert H, Kessler T, Sager HB. Colchicine impacts leukocyte trafficking in atherosclerosis and reduces vascular inflammation. Front Immunol. 2022;13:898690. - PMC - PubMed
    1. Imazio M, Gaita F, LeWinter M. Evaluation and treatment of pericarditis: a systematic review. JAMA. 2015;314:1498–506. - PubMed
    1. Kytö V, Matti Niemelä M. Acute pericarditis. Duodecim. 2017;133:391–396. - PubMed
    1. Galluzzo A, Imazio M. Advances in medical therapy for pericardial diseases. Expert Rev Cardiovasc Ther. 2018;16:635–643. - PubMed
    1. Mewton N, Roubille F, Bresson D, Prieur C, Bouleti C, Bochaton T, Ivanes F, Dubreuil O, Biere L, Hayek A, Derimay F, Akodad M, Alos B, Haider L, El Jonhy N, Daw R, De Bourguignon C, Dhelens C, Finet G, Bonnefoy-Cudraz E, Bidaux G, Boutitie F, Maucort-Boulch D, Croisille P, Rioufol G, Prunier F, Angoulvant D. Effect of colchicine on myocardial injury in acute myocardial infarction. Circulation. 2021;144:859–869. - PMC - PubMed

Publication types

LinkOut - more resources