Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 May 2:14:1381894.
doi: 10.3389/fonc.2024.1381894. eCollection 2024.

The deregulation of arachidonic acid metabolism in ovarian cancer

Qiuyi Xia #  1 , Wen Gao #  2 , Jintao Yang #  3 , Zhifang Xing  1 , Zhaodong Ji  1
Affiliations
Review

The deregulation of arachidonic acid metabolism in ovarian cancer

Qiuyi Xia et al. Front Oncol. .

Abstract

Arachidonic acid (AA) is a crucial polyunsaturated fatty acid in the human body, metabolized through the pathways of COX, LOX, and cytochrome P450 oxidase to generate various metabolites. Recent studies have indicated that AA and its metabolites play significant regulatory roles in the onset and progression of ovarian cancer. This article examines the recent research advancements on the correlation between AA metabolites and ovarian cancer, both domestically and internationally, suggesting their potential use as biological markers for early diagnosis, targeted therapy, and prognosis monitoring.

Keywords: arachidonic acid; biological marker; metabolic pathway; ovarian cancer; targeted therapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Overview of the three pathways for AA metabolism in cancer. Upon cell stimulation, phospholipase A2 induces FFAs, primarily AA derived from the lipid bilayer. The released AA is metabolized into bioactive lipid signaling molecules by three different enzymatic pathways. COX-1/2 metabolize AA to a series of prostaglandins (PGD2, PGE2, PGF2, PGH2, and PGI2).5-LO metabolizes AA to 5-HETE, LTB4, and cysteine leukotrienes, and 12-LO metabolizes AA to 12-HETE. Both subtypes of 15-LO metabolize AA to 15-HETE and, to a lesser extent, 12-HETE. Cytochrome P450 metabolizes AA to 19-/20-HETEand so on.
Figure 2
Figure 2
Overview of the pathways for the COX-mediated AA metabolism in cancer.
Figure 3
Figure 3
Overview of the pathways for the LOX-mediated AA metabolism in cancer.
Figure 4
Figure 4
Overview of the pathways for the CYP450-mediated AA metabolism in cancer.
Figure 5
Figure 5
Functional and signaling pathway enrichment analysis of AA metabolism related genes in OC. (A) Volcano plot of DEGs between ovarian cancer and non-tumor tissues based on the TCGA (OV for ovarian cancer, accessed on 20240329) and GTEx (Ovary, accessed on 20240329) database. (B) Venn diagram showing the number of DEGs and AA metabolism related genes; the intersection part is the total number of genes in the two datasets. (C) Results of GO analysis of overlapping DEGs. (D, E) Forest plot demonstrating the univariate Cox model results of 34 OS/PFS-related key genes of AA metabolism.
See this image and copyright information in PMC

References

    1. Zhang R, Siu MKY, Ngan HYS, Chan KKL. Molecular biomarkers for the early detection of ovarian cancer. Int J Mol Sci. (2022) 23(19):12041. doi: 10.3390/ijms231912041 - DOI - PMC - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. (2018) 68:394–424. doi: 10.3322/caac.21492 - DOI - PubMed
    1. Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, et al. . Ovarian cancer statistics, 2018. CA Cancer J Clin. (2018) 68:284–96. doi: 10.3322/caac.21456 - DOI - PMC - PubMed
    1. Beeghly-Fadiel A, Wilson AJ, Keene S, El Ramahi M, Xu S, Marnett LJ, et al. . Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors. J Ovarian Res. (2018) 11(1):17. doi: 10.1186/s13048-018-0389-9 - DOI - PMC - PubMed
    1. Yu W, Lei Q, Yang L, Qin G, Liu S, Wang D, et al. . Contradictory roles of lipid metabolism in immune response within the tumor microenvironment. J Hematol Oncol. (2021) 14:187. doi: 10.1186/s13045-021-01200-4 - DOI - PMC - PubMed

LinkOut - more resources