Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Feb 6;9(4):1139-1141.
doi: 10.1016/j.ekir.2024.01.063. eCollection 2024 Apr.

Bone Marrow Oxalosis

Thibaut d'Izarny-Gargas  1 , Julien Dang  1   2 , Anne Grünenwald  1 , Zeina Mechref  1 , Florent L Besson  2   3 , Sophie Ferlicot  2   4 , Mohamad Zaidan  1   2
Affiliations
Case Reports

Bone Marrow Oxalosis

Thibaut d'Izarny-Gargas et al. Kidney Int Rep. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) Histopathological analysis of the native liver specimen by hematoxylin and eosin staining revealing a normal parenchyma with sinusoid capillaries obstructed by small clusters of red blood (green arrows) and myeloid precursors as well as scattered megakaryocytes (dashed blue arrows) consistent with extramedullary hematopoiesis. (b) Bone marrow biopsy showing diffuse oxalate crystals deposits that appears highly birefringent on polarized light microscopy (inset) combined with severe alterations of the bone marrow architecture (not shown), consistent with bone marrow failure. (c) (Left) Contrast-enhanced abdominal computed tomography-scan showing massive splenomegaly (red asterisk); (Right) 111In-chloride scintigraphy showed a marked reduction in the uptake of the tracer by the marrow, and a significant uptake by the spleen, consistent with the diagnosis of bone marrow failure and spleen extramedullary erythropoiesis.
See this image and copyright information in PMC

References

    1. Singh P., Viehman J.K., Mehta R.A., et al. Clinical characterization of primary hyperoxaluria type 3 in comparison with types 1 and 2. Nephrol Dial Transplant. 2022;37:869–875. doi: 10.1093/ndt/gfab027. - DOI - PMC - PubMed
    1. Devresse A., Cochat P., Godefroid N., Kanaan N. Transplantation for primary hyperoxaluria Type 1: designing new strategies in the era of promising therapeutic perspectives. Kidney Int Rep. 2020;5:2136–2145. doi: 10.1016/j.ekir.2020.09.022. - DOI - PMC - PubMed
    1. Groothoff J.W., Metry E., Deesker L., et al. Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope. Nat Rev Nephrol. 2023;19:194–211. doi: 10.1038/s41581-022-00661-1. - DOI - PubMed

Publication types

LinkOut - more resources