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. 2024 Mar;10(1):72-78.
doi: 10.5114/ceh.2024.134141. Epub 2024 Jan 4.

Impact of CT texture analysis on complication rate in CT-guided liver biopsies

Maike Niebur  1 , Jakob Leonhardi  1 , Anne-Kathrin Höhn  1 , Manuel Florian Struck  1 , Sebastian Ebel  1 , Gordian Prasse  1 , Timm Denecke  1 , Hans-Jonas Meyer  1
Affiliations

Impact of CT texture analysis on complication rate in CT-guided liver biopsies

Maike Niebur et al. Clin Exp Hepatol. 2024 Mar.

Abstract

Aim of the study: Texture analysis derived from computed tomography (CT) involves quantitative imaging parameters characterizing possible valuable associations with clinical purposes. Their prognostic capability in patients undergoing percutaneous CT-guided liver biopsy to identify associations with postinterventional bleeding complications and biopsy success is not sufficiently explored.

Material and methods: Three hundred fifteen patients (124 female, 39%) with a mean age of 62.5 ±10.2 years underwent percutaneous CT-guided liver biopsy and were analyzed regarding clinical, procedure-related, and CT texture features.

Results: Thirty patients (9.5%) presented with bleeding after biopsy (including two requiring interventional treatment), whereas 46 patients (14.6%) had negative biopsy successes. Distance of lesion from liver capsule was statistically significantly different in patients with and without bleeding (p = 0.015). Several texture features were statistically significantly different between the groups, S(0,1)SumAverg having the highest significance (p = 0.004). Regarding unsuccessful biopsy results, liver fibrosis was the only clinical feature with statistical significance (p = 0.049). Only two texture features (S(4,-4)InvDfMom and Teta3) were statistically different between the groups according to the biopsy result.

Conclusions: Several CT texture features of the target lesion and the length from the capsule to the lesion were associated with bleeding complications after CT-guided percutaneous liver biopsy. This could be used to identify patients at risk at the beginning of the procedure.

Keywords: CT; hemorrhage; liver biopsy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Representative cases of the patient sample. A) 68-year-old female patient, no steatosis, no fibrosis, diagnostic biopsy with benign result, platelet count 316,000/μl, distance to liver capsule 0 mm, no hemorrhage. B) 61-year-old female patient, steatosis degree 5%, minimal fibrosis, non-diagnostic biopsy, platelet count 81,000/μl, distance to liver capsule 13 mm, no hemorrhage
Fig. 2
Fig. 2
ROC curves of the prediction models of hemorrhage based on clinical and texture features
See this image and copyright information in PMC

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References

    1. Mielgo A, Schmid MC. Liver tropism in cancer: The hepatic metastatic niche. Cold Spring Harb Perspect Med 2020; 10: a037259. - PMC - PubMed
    1. Ariff B, Lloyd CR, Khan S, et al. . Imaging of liver cancer. World J Gastroenterol 2009; 15: 1289-300. - PMC - PubMed
    1. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362: 1907-1917. - PubMed
    1. McGlynn KA, Petrick JL, El-Serag HB. Epidemiology of hepatocellular carcinoma. Hepatology 2021; 73 Suppl 1: 4-13. - PMC - PubMed
    1. Haj-Mirzaian A, Kadivar A, Kamel IR, Zaheer A. Updates on imaging of liver tumors. Curr Oncol Rep 2020; 22: 46. - PubMed