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. 2021 Sep 1;31(3):344-352.
doi: 10.5152/pcp.2021.21817. eCollection 2021 Sep.

The Use of Tamoxifen as a Potential Treatment for Bipolar Disorder

Noy Bagdadi  1 , Abed N Azab  2   3 , Rachel Shvartsur  2   3
Affiliations

The Use of Tamoxifen as a Potential Treatment for Bipolar Disorder

Noy Bagdadi et al. Psychiatry Clin Psychopharmacol. .

Abstract

Bipolar disorder (BD) is a chronic mental disease that substantially affects the patient's quality of life and causes significant morbidity and mortality. Although there are a variety of available treatments, therapeutic intervention is not beneficial in many cases and recurrence rates remain high. Recent data suggested tamoxifen, a drug with a wide range of activities, as a potential treatment for reducing manic symptoms of BD. Tamoxifen's therapeutic effect on bipolar mania has not been fully elucidated, but it is believed to biochemically operate on protein kinase C (PKC) inhibition. In this article, we review preclinical and clinical studies investigating the efficacy of tamoxifen as a potential treatment for bipolar manic patients.

Keywords: Antimanic treatment; bipolar disorder; mania; protein kinase C; tamoxifen.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

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