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[Preprint]. 2024 May 7:2024.05.06.24306947.
doi: 10.1101/2024.05.06.24306947.

Toward personalized skin cancer care: multiple skin cancer development in five cohorts

Lee Wheless  1   2   3 , Kai-Ping Liao  4 , Siwei Zheng  5 , Yao Li  4 , Lydia Yao  5 , Yaomin Xu  5 , Christopher Madden  6 , Jacqueline Ike  7 , Isabelle T Smith  8 , Dominique Mosley  9 , Sarah Grossarth  10 , Rebecca I Hartman  11   12 , Otis Wilson  1 , Adriana Hung  1   13 , Mackenzie R Wehner  4   14
Affiliations

Toward personalized skin cancer care: multiple skin cancer development in five cohorts

Lee Wheless et al. medRxiv. .

Update in

Abstract

Importance: Many patients will develop more than one skin cancer, however most research to date has examined only case status.

Objective: Describe the frequency and timing of the treatment of multiple skin cancers in individual patients over time.

Design: Longitudinal claims and electronic health record-based cohort study.

Setting: Vanderbilt University Medical Center database called the Synthetic Derivative, VA, Medicare, Optum Clinformatics® Data Mart Database, IBM Marketscan.

Participants: All patients with a Current Procedural Terminology code for the surgical management of a skin cancer in each of five cohorts.

Exposures: None.

Main outcomes and measures: The number of CPT codes for skin cancer treatment in each individual occurring on the same day as an ICD code for skin cancer over time.

Results: Our cohort included 5,508,374 patients and 13,102,123 total skin cancers treated.

Conclusions and relevance: Nearly half of patients treated for skin cancer were treated for more than one skin cancer. Patients who have not developed a second skin cancer by 2 years after the first are unlikely to develop multiple skin cancers within the following 5 years. Better data formatting will allow for improved granularity in identifying individuals at high risk for multiple skin cancers and those unlikely to benefit from continued annual surveillance. Resource planning should take into account not just the number of skin cancer cases, but the individual burden of disease.

Keywords: cohort study; epidemiology; skin cancer.

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Conflict of interest statement

Conflict of interest: The authors have no conflicts to declare

Figures

Figure 1.
Figure 1.
Mean cumulative function for the total number of skin cancers over time among patients in the overall VINCI cohort stratified by patient age at first skin cancer.
Figure 2.
Figure 2.
Individual-level cumulative incidence of skin cancers over time among patients in the VINCI cohort with 50 or more skin cancers treated.
See this image and copyright information in PMC

References

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