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Review
. 2024 May;36(5):682-687.
doi: 10.1016/j.sdentj.2024.02.003. Epub 2024 Feb 15.

Papillon-Lefèvre syndrome in dental pediatric patient: A comprehensive review

Kaminedi Raja Rajeswari  1 , Rahaf Almansour  2 , Farah Alrajhi  2 , Alanoud Fahad Binmeqren  2 , Maram Shayan Albaqami  2 , Raghd Abdullah Albarrak  2
Affiliations
Review

Papillon-Lefèvre syndrome in dental pediatric patient: A comprehensive review

Kaminedi Raja Rajeswari et al. Saudi Dent J. 2024 May.

Abstract

Introduction: Papillon-Lefèvre syndrome (PLS) is an autosomal recessive genetic disorder characterized by the presence of palmoplantar hyperkeratosis on the hands and feet, as well as severe periodontal disease affecting both the primary and permanent teeth, which can lead to premature tooth loss.

Aims: This review aimed to characterize the etiology, clinical manifestations, diagnosis, and recent dental management strategies of pediatric patients with PLS.

Material and methods: A comprehensive search of the electronic literature was conducted using specific keywords such as "Papillon-Lefèvre syndrome in dentistry," "Etiology of Papillon-Lefèvre syndrome," "Oral manifestations of Papillon-Lefèvre syndrome," "Management of Papillon-Lefèvre syndrome," and "Papillon-Lefèvre syndrome." A total of 47 publications that provided relevant information and discussed the various aspects of PLS were identified.

Conclusion: The management of PLS necessitates a multidisciplinary approach, including the active involvement of a dental surgeon, dermatologist, and pediatrician to ensure comprehensive care. Extraction of primary teeth and administration of antibiotics is a successful treatment strategy, while placement of removable partial denture is the best option for pediatric patients.

Keywords: Clinical manifestations; Diagnosis papillon–lefevre syndrome; Etiology papillon–lefevre syndrome; Management papillon–lefevre syndrome; Papillon–lefevre syndrome.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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