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Case Reports
. 2024 Jan 31:11:2329048X241227347.
doi: 10.1177/2329048X241227347. eCollection 2024 Jan-Dec.

Mercury Induced Autoimmunity: A Case of CASPR2/LGI1 Autoimmune Encephalitis in a 14-Month-old

Ariel Heller  1 , Krystal Nolan  2 , Salvatore Rametta  1
Affiliations
Case Reports

Mercury Induced Autoimmunity: A Case of CASPR2/LGI1 Autoimmune Encephalitis in a 14-Month-old

Ariel Heller et al. Child Neurol Open. .

Abstract

Contactin-associated protein-like 2 (CASPR2) autoantibodies are among those associated with several syndromes with effects on both the central and peripheral nervous systems including neuropathy and encephalitis and is most commonly seen in middle-aged to elderly males. We present a case of autoimmune encephalitis in a 14-month-old female presenting with altered mental status, refusal to bear weight, and hypertension in the setting of mercury exposure. This is the youngest reported case of CASPR2/LGI1/VGKC antibody associated autoimmune encephalitis stimulated by mercury exposure.

Keywords: autoimmune encephalitis; heavy metal; mercury; neuropathy.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

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