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. 1985 Sep;37(5):868-72.

Chromosomal localization of the human alpha 1-antitrypsin gene (PI) to 14q31-32

W T Schroeder, M F Miller, S L Woo, G F Saunders

Chromosomal localization of the human alpha 1-antitrypsin gene (PI) to 14q31-32

W T Schroeder et al. Am J Hum Genet. 1985 Sep.

Abstract

In situ hybridization of a recombinant cDNA probe containing the human alpha 1-antitrypsin gene to metaphase chromosomes demonstrated significant hybridization to chromosomal segment 14q31-32. A high percentage of cells analyzed (31%) displayed labeling on chromosome 14. Of all labeled sites on chromosome 14, 60% were found on segment 14q31-32. These results refine the previous assignment of the human alpha 1-antitrypsin gene to segment 14q24.1-32.1.

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