BCR::ABL1 digital PCR for treatment-free remission prediction in chronic myeloid leukemia patients: An individual participant data meta-analysis

Camille Kockerols¹, Peter J M Valk², Stéphanie Dulucq³, Franck-Emmanuel Nicolini⁴, François-Xavier Mahon^{5

6}, Ehab Atallah⁷, Michael J Mauro⁸, Jerald P Radich⁹, Simona Bernardi¹⁰, Domenico Russo¹⁰, Mirko Farina¹⁰, Silvia Mori¹¹, Carlo Gambacorti-Passerini^{11

12}, Ivan Civettini^{11

12}, Liu Lu¹³, David Yeung¹³, Susan Branford^{14

15

16}, Gioia Colafigli¹⁷, Massimo Breccia¹⁷, Pauline Hogenbirk², Joost van Rosmalen^{18

19}, Jan J Cornelissen², Peter E Westerweel¹

Affiliations

¹ Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
² Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
³ Laboratory of Hematology, Hôpital Haut Lévêque, University hospital of Bordeaux, Pessac, France.
⁴ Department of Hematology, Centre Léon Bérard and CRCL, Lyon, France.
⁵ Department of Hematology, Institut Bergonié, Bordeaux, France.
⁶ INSERM Unit BRIC 1312, Bordeaux University, Bordeaux, France.
⁷ Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
⁸ Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
⁹ Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
¹⁰ Department of Clinical and Experimental Sciences, Hematology 2 and Bone Marrow Transplant Center, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy.
¹¹ Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
¹² Department of Hematology, S. Gerardo Hospital, Monza, Italy.
¹³ South Australia Health and Medical Research Institute, University of Adelaide Medical School and Precision Cancer Medicine Theme, Adelaide, Australia.
¹⁴ Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
¹⁵ Clinical and Health Sciences, University of South Australia, Adelaide, Australia.
¹⁶ School of Medicine, The University of Adelaide, Adelaide, Australia.
¹⁷ Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
¹⁸ Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.
¹⁹ Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

PMID: 38769689
DOI: 10.1002/ajh.27359

Free article

Meta-Analysis

BCR::ABL1 digital PCR for treatment-free remission prediction in chronic myeloid leukemia patients: An individual participant data meta-analysis

Camille Kockerols et al. Am J Hematol. 2024 Aug.

Free article

. 2024 Aug;99(8):1632-1635.

doi: 10.1002/ajh.27359. Epub 2024 May 20.

Authors

Affiliations

¹ Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
² Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
³ Laboratory of Hematology, Hôpital Haut Lévêque, University hospital of Bordeaux, Pessac, France.
⁴ Department of Hematology, Centre Léon Bérard and CRCL, Lyon, France.
⁵ Department of Hematology, Institut Bergonié, Bordeaux, France.
⁶ INSERM Unit BRIC 1312, Bordeaux University, Bordeaux, France.
⁷ Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
⁸ Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
⁹ Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
¹⁰ Department of Clinical and Experimental Sciences, Hematology 2 and Bone Marrow Transplant Center, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy.
¹¹ Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
¹² Department of Hematology, S. Gerardo Hospital, Monza, Italy.
¹³ South Australia Health and Medical Research Institute, University of Adelaide Medical School and Precision Cancer Medicine Theme, Adelaide, Australia.
¹⁴ Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
¹⁵ Clinical and Health Sciences, University of South Australia, Adelaide, Australia.
¹⁶ School of Medicine, The University of Adelaide, Adelaide, Australia.
¹⁷ Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
¹⁸ Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.
¹⁹ Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

PMID: 38769689
DOI: 10.1002/ajh.27359

No abstract available

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References

REFERENCES

1. Mahon FX, Rea D, Guilhot J, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010;11(11):1029‐1035.
1. Saussele S, Richter J, Guilhot J, et al. Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO‐SKI): a prespecified interim analysis of a prospective, multicentre, non‐randomised, trial. Lancet Oncol. 2018;19(6):747‐757.
1. Dulucq S, Astrugue C, Etienne G, Mahon FX, Benard A. Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukaemia patients: a systematic review of literature with a meta‐analysis of studies over the last ten years. Br J Haematol. 2020;189(3):452‐468.
1. Lee SE, Choi SY, Song HY, et al. Imatinib withdrawal syndrome and longer duration of imatinib have a close association with a lower molecular relapse after treatment discontinuation: the KID study. Haematologica. 2016;101(6):717‐723.
1. Mahon FX, Richer J, Guilhot J, et al. Cessation of tyrosine kinase inhibitors treatment in chronic myeloid leukemia patients with deep molecular response: results of the Euro‐ski trial. Blood. 2016;128(22):787.

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BCR::ABL1 digital PCR for treatment-free remission prediction in chronic myeloid leukemia patients: An individual participant data meta-analysis

Affiliations

BCR::ABL1 digital PCR for treatment-free remission prediction in chronic myeloid leukemia patients: An individual participant data meta-analysis

Authors

Affiliations

References

REFERENCES

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous