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. 2024 May 9;10(10):e30920.
doi: 10.1016/j.heliyon.2024.e30920. eCollection 2024 May 30.

Clinical factors associated with smoking cessation among smokers with Chronic Obstructive Pulmonary Disease by sex: Longitudinal analyses from French smoking cessation services

Ingrid Allagbé  1   2 , Roche Nicolas  3 , Guillaume Airagnes  1   4 , Limosin Frédéric  5   6   7 , Abdel-Ali Boussadi  8   9 , Anne-Laurence Le Faou  1   3   2
Affiliations

Clinical factors associated with smoking cessation among smokers with Chronic Obstructive Pulmonary Disease by sex: Longitudinal analyses from French smoking cessation services

Ingrid Allagbé et al. Heliyon. .

Abstract

Background: Smoking is responsible for 80 % of cases of Chronic Obstructive Pulmonary Disease (COPD), while the prognosis is improved by smoking cessation (SC). We examined clinical factors associated with SC among smokers with COPD comparing women and men.

Methods: The study comprised a cohort of 1470 smokers who visited a SC service and completed at least 28-day of follow-up visits. The outcome was smoking status at follow-up (abstinence, reduction, no change). Abstinence was defined as continuous abstinence for at least 28 days, validated by the measurement of expired Carbon Monoxide. Reduction was defined as a halving of the baseline tobacco consumption.

Results: The average age of the population was 53 (±11) years and 58.2 % were women. Men were 2 years younger than women and consulted more likely after a hospital contact, whereas women consulted on their own initiative. Women more often had a depression history, whereas men had medical comorbidities and co-addictions. There was no significant difference by sex regarding the abstinence rate (41.0 % in women vs 40.7 in men, p > 0.9). The factors significantly associated with higher abstinence rates in both sexes were: at least one previous quit attempt and number of follow-up visits ≥4. The factors negatively associated with quitting in women were diabetes, intake of mood stabilizers and consuming more than 10 cigarettes per day while having a chronic bronchitis, taking antidepressants and having consumed cannabis in the last 30 days hampered SC in men.

Conclusions: Concerning factors associated with SC, few differences were found between female and male smokers suffering from COPD. However, due to the different medical and smoking behavior characteristics according to sex, it might be important to take these differences into account in order to provide tailored SC management.

Keywords: COPD; Nicotine replacement therapy; Smoking cessation; Smoking cessation services; Tobacco; Varenicline.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Allagbé Ingrid: Pfizer grant for research and communication on CDTnet data. Roche Nicolas: Reports grants and personal fees from Boehringer Ingelheim, Pfizer and Novartis, personal fees from Teva, GSK, AstraZeneca, Chiesi, Mundipharma, Cipla, Sanofi, Sandoz, 3 M, Zambon, outside the submitted work. Airagnes Guillaume: received fees from Lundbeck, Pierre Fabre and Pfizer, unrelated to the article. Limosin Frédéric: received fees from Lundbeck, unrelated to the article. Le Faou Anne-Laurence: conference fees in a conference organized by Pfizer in 2021, unrelated to the article. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flowchart of the study population.
See this image and copyright information in PMC

References

    1. Allagbé I., Le Faou A.L., Thomas D., et al. Tobacco-related cardiovascular risk in women: new issues and therapeutic perspectives. Arch Cardiovasc Dis. 2021;114(11):694–706. - PubMed
    1. Bonaldi C., Boussac M., Nguyen-Thanh Viêt. Estimation du nombre de décès attribuables au tabagisme, en france de 2000 à 2015. Bull Epidémiol Hebd. 2019 doi: 10.13140/rg.2.2.31002.49601. Published online. - DOI
    1. Fiore M.C., Jorenby D.E., Baker T.B. Don't Wait for COPD to Treat tobacco Use. Chest. 2016;149(3):617–618. doi: 10.1016/j.chest.2015.09.024. - DOI - PMC - PubMed
    1. Fuhrman C., Roche N., Vergnenègre A., Neukirch F., Giordanella J., Huchon G. Bronchite chronique : prévalence et qualité de vie; Analyse des données de l’enquête santé Insee 2002-2003. Rev. Mal. Respir. 2009;26(7):759–768. doi:RMR-09-2009-26-7-0761-8425-101019-20090633. - PubMed
    1. Burgel P.R., Laurendeau C., Raherison C., Fuhrman C., Roche N. An attempt at modeling COPD epidemiological trends in France. Respir. Res. 2018;19(1):130. doi: 10.1186/s12931-018-0827-7. - DOI - PMC - PubMed

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