Interventions for smoking cessation in hospitalised patients
- PMID: 38770804
- PMCID: PMC11106804
- DOI: 10.1002/14651858.CD001837.pub4
Interventions for smoking cessation in hospitalised patients
Abstract
Background: In 2020, 32.6% of the world's population used tobacco. Smoking contributes to many illnesses that require hospitalisation. A hospital admission may prompt a quit attempt. Initiating smoking cessation treatment, such as pharmacotherapy and/or counselling, in hospitals may be an effective preventive health strategy. Pharmacotherapies work to reduce withdrawal/craving and counselling provides behavioural skills for quitting smoking. This review updates the evidence on interventions for smoking cessation in hospitalised patients, to understand the most effective smoking cessation treatment methods for hospitalised smokers.
Objectives: To assess the effects of any type of smoking cessation programme for patients admitted to an acute care hospital.
Search methods: We used standard, extensive Cochrane search methods. The latest search date was 7 September 2022.
Selection criteria: We included randomised and quasi-randomised studies of behavioural, pharmacological or multicomponent interventions to help patients admitted to hospital quit. Interventions had to start in the hospital (including at discharge), and people had to have smoked within the last month. We excluded studies in psychiatric, substance and rehabilitation centres, as well as studies that did not measure abstinence at six months or longer.
Data collection and analysis: We used standard Cochrane methods. Our primary outcome was abstinence from smoking assessed at least six months after discharge or the start of the intervention. We used the most rigorous definition of abstinence, preferring biochemically-validated rates where reported. We used GRADE to assess the certainty of the evidence.
Main results: We included 82 studies (74 RCTs) that included 42,273 participants in the review (71 studies, 37,237 participants included in the meta-analyses); 36 studies are new to this update. We rated 10 studies as being at low risk of bias overall (low risk in all domains assessed), 48 at high risk of bias overall (high risk in at least one domain), and the remaining 24 at unclear risk. Cessation counselling versus no counselling, grouped by intensity of intervention Hospitalised patients who received smoking cessation counselling that began in the hospital and continued for more than a month after discharge had higher quit rates than patients who received no counselling in the hospital or following hospitalisation (risk ratio (RR) 1.36, 95% confidence interval (CI) 1.24 to 1.49; 28 studies, 8234 participants; high-certainty evidence). In absolute terms, this might account for an additional 76 quitters in every 1000 participants (95% CI 51 to 103). The evidence was uncertain (very low-certainty) about the effects of counselling interventions of less intensity or shorter duration (in-hospital only counselling ≤ 15 minutes: RR 1.52, 95% CI 0.80 to 2.89; 2 studies, 1417 participants; and in-hospital contact plus follow-up counselling support for ≤ 1 month: RR 1.04, 95% CI 0.90 to 1.20; 7 studies, 4627 participants) versus no counselling. There was moderate-certainty evidence, limited by imprecision, that smoking cessation counselling for at least 15 minutes in the hospital without post-discharge support led to higher quit rates than no counselling in the hospital (RR 1.27, 95% CI 1.02 to 1.58; 12 studies, 4432 participants). Pharmacotherapy versus placebo or no pharmacotherapy Nicotine replacement therapy helped more patients to quit than placebo or no pharmacotherapy (RR 1.33, 95% CI 1.05 to 1.67; 8 studies, 3838 participants; high-certainty evidence). In absolute terms, this might equate to an additional 62 quitters per 1000 participants (95% CI 9 to 126). There was moderate-certainty evidence, limited by imprecision (as CI encompassed the possibility of no difference), that varenicline helped more hospitalised patients to quit than placebo or no pharmacotherapy (RR 1.29, 95% CI 0.96 to 1.75; 4 studies, 829 participants). Evidence for bupropion was low-certainty; the point estimate indicated a modest benefit at best, but CIs were wide and incorporated clinically significant harm and clinically significant benefit (RR 1.11, 95% CI 0.86 to 1.43, 4 studies, 872 participants). Hospital-only intervention versus intervention that continues after hospital discharge Patients offered both smoking cessation counselling and pharmacotherapy after discharge had higher quit rates than patients offered counselling in hospital but not offered post-discharge support (RR 1.23, 95% CI 1.09 to 1.38; 7 studies, 5610 participants; high-certainty evidence). In absolute terms, this might equate to an additional 34 quitters per 1000 participants (95% CI 13 to 55). Post-discharge interventions offering real-time counselling without pharmacotherapy (RR 1.23, 95% CI 0.95 to 1.60, 8 studies, 2299 participants; low certainty-evidence) and those offering unscheduled counselling without pharmacotherapy (RR 0.97, 95% CI 0.83 to 1.14; 2 studies, 1598 participants; very low-certainty evidence) may have little to no effect on quit rates compared to control. Telephone quitlines versus control To provide post-discharge support, hospitals may refer patients to community-based telephone quitlines. Both comparisons relating to these interventions had wide CIs encompassing both possible harm and possible benefit, and were judged to be of very low certainty due to imprecision, inconsistency, and risk of bias (post-discharge telephone counselling versus quitline referral: RR 1.23, 95% CI 1.00 to 1.51; 3 studies, 3260 participants; quitline referral versus control: RR 1.17, 95% CI 0.70 to 1.96; 2 studies, 1870 participants).
Authors' conclusions: Offering hospitalised patients smoking cessation counselling beginning in hospital and continuing for over one month after discharge increases quit rates, compared to no hospital intervention. Counselling provided only in hospital, without post-discharge support, may have a modest impact on quit rates, but evidence is less certain. When all patients receive counselling in the hospital, high-certainty evidence indicates that providing both counselling and pharmacotherapy after discharge increases quit rates compared to no post-discharge intervention. Starting nicotine replacement or varenicline in hospitalised patients helps more patients to quit smoking than a placebo or no medication, though evidence for varenicline is only moderate-certainty due to imprecision. There is less evidence of benefit for bupropion in this setting. Some of our evidence was limited by imprecision (bupropion versus placebo and varenicline versus placebo), risk of bias, and inconsistency related to heterogeneity. Future research is needed to identify effective strategies to implement, disseminate, and sustain interventions, and to ensure cessation counselling and pharmacotherapy initiated in the hospital is sustained after discharge.
Trial registration: ClinicalTrials.gov NCT00937508 NCT02099097 NCT02106637.
Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Conflict of interest statement
JS has no known conflicts.
NAR has co‐authored Cochrane Reviews of e‐cigarettes for smoking cessation, and has received royalties from UpToDate (WoltersKluwer.com), an online medical textbook, for writing sections on smoking cessation treatment (personal payment). She received consulting fees from Achieve Life Sciences for the development of cytisinicline (also known as cytisine, an investigational smoking cessation medication that is not discussed in this review) and for serving as a member of Data Safety Monitoring Boards for 2 clinical trials (personal payments). Her institution (MGH) received funding from Achieve Life Sciences to conduct a clinical trial of the medication for smoking cessation and a Small Business grant from NIH/NIDA with NAR as one of two Principal Investigators to conduct a clinical trial of the medication for cessation of nicotine e‐cigarette use. She was the site PI and overall PI for both studies.
NAR was involved in six studies, all randomised controlled trials, included in this review. The studies and their funders are listed below. None of the funders had a role in study design, conduct, analysis, or decision to publish. NAR was not involved in study selection, data extraction, assessment of risk of bias or rating the certainty of the evidence for these studies (these tasks were performed by two independent review authors ‐ JS and CC).
Rigotti 1994 ‐ Funder: American Heart Association
Rigotti 1997 ‐ Funder: research grant from the Massachusetts Department of Public Health, USA
Rigotti 2006 ‐ Funder: Grant from National Heart Lung and Blood Institute (NHLBI) of the National Institutes of Health, USA
Rigotti 2014a ‐ Funder: Grants from NHLBI
Rigotti 2016a ‐ Funder: Grant from NHLBI
Rigotti 2022 ‐ Funder: Grant from NHLBI
JLB is an Associate Editor with Cochrane. He was not involved in the editorial process for this review. JLB has no conflicts of interest.
HT has served as an unpaid consultant for Achieve Life Sciences (specifically, volunteered scientific input into the design of a phase 3 trial) and has received nonfinancial support from Pfizer for a clinical study (specifically, donated varenicline medication for cancer patients who smoked at her institution). She also served as a multiple Principal Investigator or co‐investigator on studies that were included in this review (Rigotti 2022; Rigotti 2016a ‐ funder as above). HT was not involved in study selection, data extraction, assessment of risk of bias or rating the certainty of the evidence for these studies (these tasks were performed by two independent review authors ‐ JS and CC). HT is a healthcare professional and member of the faculty, Department of Medicine, Vanderbilt University Medical Center.
CC works as General Internist at Unisanté, Lausanne, Switzerland. CC declares that she has received honoraria from Elli‐Lilly and Septodont for two presentations in 2023 (these presentations were not related to smoking cessation; they were clinical courses on the impact of sex and gender on health); paid to institution but CC benefited.
MRM has received grant funding from Pfizer through their Investigator‐Initiated Research programme.
CS‐M: has no known conflicts.
JHB has received grant funding from Cancer Research UK and the National Institute for Health Research on related topics, but that have not directly supported this work (paid to institution). She is an Editor with the Cochrane Tobacco Addiction Group but was not involved in the editorial process for this review.
Figures
Update of
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Interventions for smoking cessation in hospitalised patients.Cochrane Database Syst Rev. 2012 May 16;5(5):CD001837. doi: 10.1002/14651858.CD001837.pub3. Cochrane Database Syst Rev. 2012. Update in: Cochrane Database Syst Rev. 2024 May 21;5:CD001837. doi: 10.1002/14651858.CD001837.pub4. PMID: 22592676 Free PMC article. Updated.
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- Kondrack R, Hilleman DE, Maciejewski SR, Grollmes TL, Cloutier DA, Mohiuddin SM. Cost analysis of an intensive smoking cessation intervention in cardiac patients. Journal of the American College of Cardiology 2008;51(10):A257.
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Molyneux 2003 {published data only}
Murray 2013a {published data only}
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- Murray RL, Leonardi-Bee J, Marsh J, Jayes L, Britton J. Is the systematic identification and treatment of smokers in secondary care effective, and does it change usual practice? American Journal of Respiratory and Critical Care Medicine 2013;187(Meeting Abstracts):A3909. [CENTRAL: 990598] [EMBASE: 71983408]
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- Murray RL, Leonardi-Bee J, Marsh J, Jayes L, Li J, Parrott S, et al. Systematic identification and treatment of smokers by hospital based cessation practitioners in a secondary care setting: cluster randomised controlled trial. BMJ 2013;347:f4004. [CENTRAL: 873086] [EMBASE: 2013464666] [PMID: ] - PMC - PubMed
Nagle 2005 {published data only}
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- Nagle AL, Hensley MJ, Schofield MJ, Koschel AJ. A randomised controlled trial to evaluate the efficacy of a nurse-provided intervention for hospitalised smokers. Australian and New Zealand Journal of Public Health 2005;29(3):285-91. - PubMed
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Ortigosa 2000 {published data only}
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Park 2015 {published data only}
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Pedersen 2005 {published data only}
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Pederson 1991 {published data only}
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Pelletier 1998 {published data only}
Planer 2011 {published data only}
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Quist‐Paulsen 2003 {published data only}
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- Brown DW. Nurse-led intervention increases smoking cessation among people with coronary heart disease. Evidence Based Healthcare 2004;8:128-30.
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- Quist-Paulsen P, Bakke PS, Gallefoss F. Does smoking cessation improve quality of life in patients with coronary heart disease? Scandinavian Cardiovascular Journal 2006;40(1):11-6. - PubMed
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Reid 2003 {published data only}
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Reid 2007 {published data only}
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Reid 2019 {published data only}
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- Reid RD, Aitken DA, McDonnell L, Armstrong A, Mullen KA, Jones L, et al. Randomized trial of an automated telephone follow-up system for smoking cessation in smokers with CHD. Canadian Journal of Cardiology 2011;27(5 Suppl 1):S67. [CENTRAL: 814379]
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- Reid RD, Aitken DA, Mullen K-A, McDonnell L, Armstrong A, LeBlanc AG, et al. Automated telephone follow-up for smoking cessation in smokers with coronary heart disease: a randomized controlled trial. Nicotine & Tobacco Research 2019;21(8):1051-7. - PubMed
Richter 2016 {published data only}
Richter 2023 {published data only}
Rigotti 1994 {published data only}
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- Rigotti NA, McKool KM, Shiffman S. Predictors of smoking cessation after coronary artery bypass graft surgery. Results of a randomized trial with 5-year follow-up. Annals of Internal Medicine 1994;120(4):287-93. - PubMed
Rigotti 1997 {published data only}
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Rigotti 2006 {published data only}
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- Rigotti NA, Thorndike AN, Regan S, McKool K, Pasternak RC, Chang Y, et al. Bupropion for smokers hospitalized with acute cardiovascular disease. American Journal of Medicine 2006;119(12):1080-7. - PubMed
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Rigotti 2014a {published data only}
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- Rigotti NA, Japuntich S, Regan S, Kelley JH, Chang Y, Reyen M, et al. Promoting smoking cessation after hospital discharge: the helping hand randomized controlled comparative effectiveness trial. Journal of General Internal Medicine 2013;28(1 Suppl):S160. [CENTRAL: 993940] [EMBASE: 71292966]
Rigotti 2016a {published data only}
Rigotti 2022 {published data only}
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- NCT03603496. Post-discharge smoking cessation strategies: Helping HAND 4. clinicaltrials.gov/ct2/show/NCT03603496 (first received 27 July 2018).
Sherman 2016a {published data only}
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- Grossman E, Link AR, Rogers E, Wang B, Sherman S. A profile of hospitalized smokers and the care they receive. Journal of General Internal Medicine 2014;29:S11. [CENTRAL: 1010140] [EMBASE: 71494706]
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- NCT01363245. Effectiveness of smoking-cessation interventions for urban hospital patients. clinicaltrials.gov/ct2/show/NCT01363245 (first received 1 June 2011).
Simon 1997 {published data only}
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- Simon JA, Solkowitz SN, Carmody TP, Browner WS. Smoking cessation after surgery - a randomized trial. Archives of Internal Medicine 1997;157:1371-6. - PubMed
Simon 2003 {published data only}
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- Simon JA, Carmody TP, Hudes ES, Snyder E, Murray J. Intensive smoking cessation counseling versus minimal counseling among hospitalized smokers treated with transdermal nicotine replacement: a randomized trial. American Journal of Medicine 2003;114(7):555-62. - PubMed
Simon 2009a {published data only}
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- Simon JA, Duncan C, Huggins J, Solkowitz S, Carmody TP. Sustained-release bupropion for hospital-based smoking cessation: a randomized trial. Nicotine & Tobacco Research 2009;11(6):663-9. - PubMed
Smith 2009b {published data only}
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- Bitton A. Intensive smoking cessation programs for hospitalized coronary patients: a proven intervention in need of implementation. Journal of Clinical Outcomes Management 2009;16(9):398-9.
Smith 2011 {published data only}
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- Smith PM, Corso L, Brown KS, Cameron R. Nurse case-managed tobacco cessation interventions for general hospital patients: results of a randomized clinical trial. Canadian Journal of Nursing Research 2011;43:98-117. - PubMed
Steinberg 2011 {published data only}
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- Steinberg MB, Randall J, Greenhaus S, Schmelzer AC, Richardson DL, Carson JL. Tobacco dependence treatment for hospitalized smokers: a randomized, controlled, pilot trial using varenicline. Addictive Behaviors 2011;36(12):1127-32. - PubMed
Stevens 1993 {published data only}
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- Stevens VJ, Glasgow RE, Hollis JF, Lichtenstein E, Vogt TM. A smoking-cessation intervention for hospital patients. Medical Care 1993;31(1):65-72. - PubMed
Stevens 2000 {published data only}
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- Allaway L, Stevens VJ. Respiratory care practitioners can provide effective smoking-cessation counseling to hospitalized smokers. Respiratory Care 1996;41(11):1026-9.
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- Stevens VJ, Glasgow RE, Hollis JF, Mount K. Implementation and effectiveness of a brief smoking-cessation intervention for hospital patients. Medical Care 2000;38(5):451-9. - PubMed
Suner‐Soler 2022 {published data only}
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- Suner-Soler R, Grau-Martin A, Terceno M, Silva Y, Maldonado E, Gras ME, et al. A clinical trial comparing smoking cessation interventions at two levels of intensity in stroke patients, stratified by the presence of insular cortex lesions. Nicotine & Tobacco Research 2022;24(1):44-52. - PubMed
Taylor 1990 {published data only}
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- Taylor CB, Houston-Miller NH, Killen JD, DeBusk RF. Smoking cessation after acute myocardial infarction: effects of a nurse-managed intervention. Annals of Internal Medicine 1990;113:118-23. - PubMed
Thomas 2016a {published data only}
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- ACTRN12612000368831. GIVE UP FOR GOOD - A study to evaluate the effectiveness of a pharmacist-led multidisciplinary smoking cessation intervention for smokers admitted to public hospitals. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=362169 (first received 26 March 2012).
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- Thomas D, Abramson M, Bonevski B, Taylor S, Poole S, Weeks G, et al. Pharmacist-led multicomponent smoking cessation intervention in Victorian public hospitals - a randomised controlled trial. Respirology 2015;20(Suppl 2):61. [CENTRAL: 1078324] [EMBASE: 71870755]
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- Thomas D, Abramson MJ, Bonevski B, Taylor S, Poole S, Weeks GR, et al. A pharmacist-led system-change smoking cessation intervention for smokers admitted to Australian public hospitals (GIVE UP FOR GOOD): study protocol for a randomised controlled trial. Trials 2013;14:148. [CENTRAL: 863879] [EMBASE: 2013336506] [PMID: ] - PMC - PubMed
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- Thomas D, Abramson MJ, Bonevski B, Taylor S, Poole SG, Paul E, et al. Integrating smoking cessation into routine care in hospitals-a randomized controlled trial. Addiction 2016;111(4):714-23. [PMID: ] - PubMed
Vial 2002 {published data only}
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- Vial RJ, Jones TE, Ruffin RE, Gilbert AL. Smoking cessation program using nicotine patches linking hospital to the community. Journal of Pharmacy Practice and Research 2002;32(1):57-62.
Warner 2016a {published data only}
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- NCT01575145. Helping hospitalized patients quit smoking. clinicaltrials.gov/ct2/show/NCT01575145 (first received 11 April 2012).
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- Warner DO, Nolan MB, Kadimpati S, Burke MV, Hanson AC, Schroeder DR. Quitline tobacco interventions in hospitalized patients: a randomized trial. American Journal of Preventive Medicine 2016;51(4):473-84. [PMID: ] - PubMed
Windle 2018 {published data only}
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- Eisenberg MJ, Windle SB, Roy N, Old W, Grondin FR, Bata I, et al. Varenicline for smoking cessation in hospitalized patients with acute coronary syndrome. Circulation 2016;133(1):21-30. [CENTRAL: 1127550] [EMBASE: 2015513719] [PMID: ] - PubMed
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- NCT00794573. Evaluation of varenicline (Chantix) for smoking cessation in patients with post-acute coronary syndrome: the EVITA trial. clinicaltrials.gov/ct2/show/NCT00794573 (first received 20 November 2008).
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- NCT03209622. Smoking cessation after acute coronary syndrome. clinicaltrials.gov/show/NCT03209622 (first received 6 July 2017).
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- Prochazka AV. Varenicline increased smoking cessation at 24 weeks in patients hospitalized with ACS and motivated to quit. ACP Journal Club 2016;164(8):6. - PubMed
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- Windle SB, Bata I, Madan M, Abramson BL, Dehghani P, Sharma S, et al. Incidence of cardiovascular events with varenicline for smoking cessation post-acute coronary syndrome. Canadian Journal of Cardiology 2013;29(10 Suppl):S278-9. [CENTRAL: 993939] [EMBASE: 71204265]
References to studies excluded from this review
Adamuz 2015 {published data only}
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- Adamuz J, Viasus D, Simonetti A, Jimenez-Martinez E, Molero L, Gonzalez-Samartino M, et al. Impact of an educational program to reduce healthcare resources in community-acquired pneumonia: the EDUCAP randomized controlled trial. PLOS One 2015;10(10):e0140202. [CENTRAL: 1125611] [DOI: 10.1371/journal.pone.0140202] [EMBASE: 2015553631] [PMID: ] - DOI - PMC - PubMed
Chen 2021 {published data only}
Johns 2017 {published data only}
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- Johns D. Randomised controlled trial comparing nicotine replacement therapy (NRT) and counselling on smoking cessation in patients prone to lung cancer using bed font micro-smokerlyzer. Supportive Care in Cancer 2017;25(2):S102. [DOI: 10.1007/s00520-017-3704-x] - DOI
Jones 2012 {published data only}
Kadda 2015 {published data only}
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- Kadda O, Kotanidou A, Manginas A, Stavridis G, Nanas S, Panagiotakos DB. Lifestyle intervention and one-year prognosis of patients following open heart surgery: a randomised clinical trial. Journal of Clinical Nursing 2015;24(11-12):1611-21. [CENTRAL: 1134530] [DOI: 10.1111/jocn.12762] [PMID: ] - DOI - PubMed
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Lepage 2014 {published data only}
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- Lepage M, Renaud L, Champagne F, Rivard M. Strategies to increase the brief interventions in smoking cessation among nurses in hospital settings: experimental study [French] [Evaluation comparative de strategies visant a augmenter les interventions de courte duree pour le sevrage tabagique aupres du personnel infirmier de milieux hospitaliers: resultats d'une etude experimentale]. Recherche en Soins Infirmiers 2014;1(116):57-69. [CENTRAL: 992594] [PMID: ] - PubMed
Molina Ruiz 2014 {published data only}
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- Molina Ruiz F, Navarro Luque G, Ariza Canete J, Alcantara Reyes JM, Herrera Gutierrez N, Trapiello Gonzalez L, et al. Impact of a group educational intervention on the prevention of smoking uptake in cardiac patients after discharge: a randomized clinical trial. European Journal of Cardiovascular Nursing 2014;13:S47. [CENTRAL: 1054154] [EMBASE: 71683052]
Pathak 2013 {published data only}ISRCTN66928309
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- Pathak V, Rendon IS, Lupu R, Tactuk N, Olutade T, Durham C, et al. Outcome of nicotine replacement therapy in patients admitted to ICU: a randomized controlled double-blind prospective pilot study. Respiratory Care 2013;58(10):1625-9. [CENTRAL: 914059] [DOI: 10.4187/respcare.01791] [EMBASE: 2013608314] [ISRCTN66928309/ISRCTN] [PMID: ] - DOI - PubMed
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- Pathak V, Rendon ISH, Lupu R, Tactuk N, Olutade T, Vegesna V, et al. Outcome of nicotine replacement therapy in patients admitted to intensive care unit: a randomized case-control double blinded prospective pilot study. European Respiratory Journal 2011;38(55):p1793. [CENTRAL: 990199] [EMBASE: 72116518]
Pfaeffli 2015 {published data only}
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- Pfaeffli DL, Whittaker R, Jiang Y, Stewart R, Rolleston A, Maddison R. Text message and internet support for coronary heart disease self-management: results from the Text4Heart randomized controlled trial. Journal of Medical Internet Research 2015;17(10):e237. [CENTRAL: 1169317] [DOI: 10.2196/jmir.4944] [PMID: ] - DOI - PMC - PubMed
Sarna 2012 {published data only}
Schulte 2016 {published data only}
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- Schulte DM, Duster M, Warrack S, Valentine S, Jorenby D, Shirley D, et al. Feasibility and patient satisfaction with smoking cessation interventions for prevention of healthcare-associated infections in inpatients. Substance Abuse Treatment, Prevention, and Policy 2016;11:15. [DOI: 10.1186/s13011-016-0059-0] [PMID: ] - DOI - PMC - PubMed
Septauli 2021 {published data only}
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- Septauli KM, Susanto AD, Agustin H, Ginting TT, Taufik FF. Effectiveness of 4T (Tanya, Telaah, Tolong nasehati dan Tindak lanjut) for quit smoking rate in patient with lung tuberculosis at Persahabatan Hospital (pre-eliminary study). Tobacco Induced Diseases 2021;19(Suppl 1):A185. [DOI: 10.18332/tid/141390] - DOI
Sienkiewicz‐Jarosz 2014a {published data only}
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- Sienkiewicz-Jarosz H, Glebicka A, Restel M, Kurkowska-Jastrzebska I, Bozek M, Ryglewicz D, et al. Antismoking interventions in stroke patients - Polish perspective. Journal of the Neurological Sciences 2015;357:e410-1. [CENTRAL: 1163971] [EMBASE: 72092510]
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- Sienkiewicz-Jarosz H, Jastrzebska A, Restel M, Kurkowska-Jastrzebska I, Ryglewicz D, Bienkowski P. Effectiveness of three anti-smoking interventions of different intensities in patients after ischemic stroke - a pilot data from a randomized controlled trial. European Journal of Neurology 2014;21(Suppl 1):355. [ABSTRACT NUMBER: EP4206] [CENTRAL: 993975] [EMBASE: 71481297]
Stockings 2014 {published data only}
-
- ACTRN12609000465257. The effect of an integrated smoking care program on the reduction and abstinence of smoking in mental health inpatients following discharge from hospital. www.anzctr.org.au/trial_view.aspx?ID=83938 (first received 2 June 2009).
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- Stockings EA, Bowman JA, Baker AL, Terry M, Clancy R, Wye PM, et al. Impact of a postdischarge smoking cessation intervention for smokers admitted to an inpatient psychiatric facility: a randomized controlled trial. Nicotine & Tobacco Research 2014;16(11):1417-28. [CENTRAL: 1036731] [DOI: 10.1093/ntr/ntu097] [EMBASE: 2014920180] [PMID: ] - DOI - PubMed
Suhaj 2016 {published data only}
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- Suhaj A, Manu MK, Unnikrishnan MK, Vijayanarayana K, Mallikarjuna RC. Effectiveness of clinical pharmacist intervention on health-related quality of life in chronic obstructive pulmonary disorder patients - a randomized controlled study. Journal of Clinical Pharmacy and Therapeutics 2016;41(1):78-83. [CENTRAL: 1133032] [DOI: 10.1111/jcpt.12353] [EMBASE: 20160068356] [PMID: ] - DOI - PubMed
Van Nostrand 2014 {published data only}
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- Van Nostrand K, Fisher K, Khan BA. Smoking cessation after surviving critical illness - is it feasible? - authors experience with implementation and recruitment. American Journal of Respiratory and Critical Care Medicine 2014;189:A4482. [CENTRAL: 1038473] [EMBASE: 72046433]
Wong 2012 {published data only}
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- Wong J, Abrishami A, Yang Y, Zaki A, Friedman Z, Selby P, et al. A perioperative smoking cessation intervention with varenicline: a double-blind, randomized, placebo-controlled trial. Anesthesiology 2012;117(4):755-64. [CENTRAL: 835869] [DOI: 10.1097/ALN.0b013e3182698b42] [EMBASE: 2012567287] [PMID: ] - DOI - PubMed
Yujie 2014a {published data only}
-
- Yujie W, Huliang L. GW25-e5131 Efficacy and safety of varenicline for smoking cessation in patients with CAD undergoing PCI. Journal of the American College of Cardiology 2014;64(Suppl 16):C207. [CENTRAL: 1054389] [EMBASE: 71665049]
References to ongoing studies
ACTRN12620001255976 {published data only}
-
- ACTRN12620001255976. Use of text messaging support to aid smoking cessation in patients presenting for surgery (TextPOP). www.australianclinicaltrials.gov.au/anzctr/trial/ACTRN12620001255976 (first received 24 November 2020).
Almonacid 2020 {published data only}
-
- Almonacid I, Olaya L, Cuevas V, Castillo JS, Becerra N, Delgado J, et al. Effectiveness of brief counseling in a hospital setting for smoking cessation and risky alcohol drinking reduction: randomized clinical trial protocol. Revista Colombiana de Psiquiatria 2020;S0034-7450(20):30085-8. [DOI: 10.1016/j.rcp.2020.06.005] - DOI
Chu 2019 {published data only}
Cossette 2012 {published data only}
-
- Cossette S, Frasure-Smith N, Robert M, Chouinard MC, Juneau M, Guertin MC, et al. A pilot randomized trial of a smoking cessation nursing intervention in cardiac patients after hospital discharge. Journal Canadien en Soins Infirmiers Cardio-Vasculaires [Canadian Journal of Cardiovascular Nursing] 2012;22(4):16-26. [PMID: ] - PubMed
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- ISRCTN26884027. Evaluation of a nursing intervention for smoking cessation in cardiac patients: a pilot randomised study. www.isrctn.com/ISRCTN26884027?q=ISRCTN26884027 (first received 1 October 2008).
CTRI/2019/09/021406 {published data only}
-
- CTRI/2019/09/021406. To determine the best behavioral change strategy for tobacco cessation when provided in hospital to tobacco users. www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=36913 (first received 25 September 2019).
DRKS00013466 {published data only}
-
- DRKS00013466. Implementation and evaluation of the effectivity of an inpatient smoking cessation therapy by a mobile applicable therapy team. www.drks.de/DRKS00013466 (first received 1 April 2019).
Gobarani 2022 {published data only}
-
- ACTRN12618001792213. Varenicline and nicotine replacement therapy for smokers admitted to hospitals. anzctr.org.au/ACTRN12618001792213.aspx (first received 2 November 2018).
-
- Gobarani RK, Abramson MJ, Bonevski B, Weeks GR, Dooley MJ, Smith BJ, et al. The efficacy and safety of varenicline alone versus in combination with nicotine lozenges for smoking cessation among hospitalised smokers (VANISH): study protocol for a randomised, placebo-controlled trial. BMJ Open 2020;10(10):e038184. - PMC - PubMed
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- Gobarani RK, Weeks GR, Abramson MJ, Bonevski B, Liau SJ, George J. Experiences of hospitalized smokers initiated on varenicline as part of a pragmatic smoking cessation trial. Journal of Addictive Diseases 2023;41(3):242-50. - PubMed
NCT01413516 {published data only}
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- NCT01413516. A two-part pilot study of dosing, safety and efficacy of varenicline initiated during an acute smoke-free hospitalization and continued post-hospitalization. clinicaltrials.gov/show/NCT01413516 (first received 10 August 2011).
NCT02099097 {published data only}
-
- NCT02099097. Quit IT: preliminary testing of a web-based, 3D coping skills game to increase quitting self-efficacy for maintaining smoking abstinence following hospitalization. clinicaltrials.gov/show/NCT02099097 (first received 28 March 2014).
NCT02106637 {published data only}
-
- NCT02106637. Early in-hospital initiation of pharmacotherapy for smoking cessation, concomitant with nurse-led support, in patients after an acute coronary syndrome (ACS). clinicaltrials.gov/show/NCT02106637 (first received 8 April 2014).
NCT02470923 {published data only}
-
- NCT02470923. In-patient smoking cessation intervention using counseling, spirometry and nicotine replacement therapy. clinicaltrials.gov/show/NCT02470923 (first received 12 June 2015).
NCT04590404 {published data only}
-
- NCT04590404. Informed smoking treatment: the MIST RCT. clinicaltrials.gov/show/NCT04590404 (first received 19 October 2020).
NCT05192031 {published data only}
-
- NCT05192031. Implementation of smoking cessation support during lung cancer workup. clinicaltrials.gov/show/NCT05192031 (first received 14 January 2022).
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References to other published versions of this review
Munafo 2001
Rigotti 2001
Rigotti 2003
Rigotti 2007
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