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Multicenter Study
. 2024 Nov;46(11):2762-2775.
doi: 10.1002/hed.27746. Epub 2024 May 21.

Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

Jatin P Shah  1 , Helena Levyn  1 , Cristina Valero  1 , Dauren Adilbay  1 , Alana Eagan  1 , Junting Zheng  2 , Mithat Gonen  2 , Marc Cohen  1 , Snehal Patel  1 , Ian Ganly  1 , Prathamesh Pai  3 , Paolo Castelnuovo  4 , Fang Ju Gao  5 , Cesare Piazza  6 , Piero Nicolai  6 , Ben Panizza  7 , James Bowman  7 , Catherine Barnett  7 , Luiz P Kowalski  8   9 , Ronaldo Toledo  8 , Dan M Fliss  10 , John DeAlmeida  11 , Ian Witterick  11 , Philippe Herman  12 , Walter Fontanella  13 , Gregorio Sanchez Aniceto  14 , Sefik Hosal  15 , Serdar Ozer  15 , Subramania Iyer  16 , Richard Harvey  17 , C Rene Leemans  18 , Jan-Jaap Hendrickx  18 , Marcelo Figari  19 , Luis Boccalatte  19 , Ken Ichi Nibu  20 , Peter Clarke  21 , Catherine Rennie  21 , Zhu Yi Ming  22 , Claudio Cernea  9 , Sergio Goncalves  9 , Rodney Schlosser  23 , Fernando Dias  24 , Zoukaa Sargi  25 , Shahzada Ahmed  26 , Wojciech Golusinski  27 , Se Heon Kim  28 , Shirley Y Su  29 , Shaan M Raza  30 , Franco DeMonte  30 , Ehab Hanna  29
Affiliations
Multicenter Study

Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

Jatin P Shah et al. Head Neck. 2024 Nov.

Abstract

Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.

Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.

Results: The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.

Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

Keywords: global collaboration; multimodality treatment; prognostic factors; skull base tumors; survival outcomes.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.
Oncoprint of patient demographics
Figure 2.
Figure 2.
Distribution of histology
Figure 3.
Figure 3.
Overall Survival Curves Across Entire Cohort, Primary, and Recurrent Tumors
Figure 4.
Figure 4.
Disease Specific Survival Curves Across Entire Cohort, Primary, and Recurrent
Figure 5.
Figure 5.
Recurrence Free Survival (RFS) Curves Across Entire Cohort, Primary, and Recurrent Tumors (A), and Local, Regional and Distant Recurrence-Free Probability Curves (B)
Figure 5.
Figure 5.
Recurrence Free Survival (RFS) Curves Across Entire Cohort, Primary, and Recurrent Tumors (A), and Local, Regional and Distant Recurrence-Free Probability Curves (B)
Figure 6.
Figure 6.
Overall Survival (A), Disease Specific Survival (B) and Recurrence Free Survival (C) Curves Comparing Patients Undergoing Surgery Alone vs Combinations of Prior/Neoadjuvant and Radiotherapy (RT) and Chemoradiotherapy (CRT) Adjuvant Treatment.
See this image and copyright information in PMC

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