Machine Learning Models for Parkinson Disease: Systematic Review

Abstract

Background: With the increasing availability of data, computing resources, and easier-to-use software libraries, machine learning (ML) is increasingly used in disease detection and prediction, including for Parkinson disease (PD). Despite the large number of studies published every year, very few ML systems have been adopted for real-world use. In particular, a lack of external validity may result in poor performance of these systems in clinical practice. Additional methodological issues in ML design and reporting can also hinder clinical adoption, even for applications that would benefit from such data-driven systems.

Objective: To sample the current ML practices in PD applications, we conducted a systematic review of studies published in 2020 and 2021 that used ML models to diagnose PD or track PD progression.

Methods: We conducted a systematic literature review in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines in PubMed between January 2020 and April 2021, using the following exact string: "Parkinson's" AND ("ML" OR "prediction" OR "classification" OR "detection" or "artificial intelligence" OR "AI"). The search resulted in 1085 publications. After a search query and review, we found 113 publications that used ML for the classification or regression-based prediction of PD or PD-related symptoms.

Results: Only 65.5% (74/113) of studies used a holdout test set to avoid potentially inflated accuracies, and approximately half (25/46, 54%) of the studies without a holdout test set did not state this as a potential concern. Surprisingly, 38.9% (44/113) of studies did not report on how or if models were tuned, and an additional 27.4% (31/113) used ad hoc model tuning, which is generally frowned upon in ML model optimization. Only 15% (17/113) of studies performed direct comparisons of results with other models, severely limiting the interpretation of results.

Conclusions: This review highlights the notable limitations of current ML systems and techniques that may contribute to a gap between reported performance in research and the real-life applicability of ML models aiming to detect and predict diseases such as PD.

Keywords: PRISMA; Parkinson disease; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; clinical adoption; deep learning; machine learning; systematic review; validation techniques.

Figure 1.. Number of studies with more than 30% class imbalance and the percentage of studies that applied the class imbalance strategies, separated by PD prediction target. In the PD versus non-PD classification, PD versus non-PD versus other diseases classification, PD severity prediction, and PD symptoms quantification and progression prediction categories, 46% (27/59), 67% (16/24), 100% (30/30), and 40% (4/10) had class imbalance, but only 8% (5/59), 21% (8/30), 27% (8/30), and 10% (1/10) applied mitigation strategies, respectively. PD: Parkinson disease.