Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 21;19(5):e0304041.
doi: 10.1371/journal.pone.0304041. eCollection 2024.

lncRNA CDKN2B-AS1 is downregulated in patients with ventricular fibrillation in acute myocardial infarction

Ricardo Pan-Lizcano  1 , Lucía Núñez  1   2 , Pablo Piñón  3 , Guillermo Aldama  3 , Xacobe Flores  3 , Ramón Calviño-Santos  3   4 , José Manuel Vázquez-Rodríguez  3   4 , Manuel Hermida-Prieto  1
Affiliations

lncRNA CDKN2B-AS1 is downregulated in patients with ventricular fibrillation in acute myocardial infarction

Ricardo Pan-Lizcano et al. PLoS One. .

Abstract

Ventricular fibrillation (VF) in acute myocardial infarction (AMI) is the main cause of deaths occurring in the acute phase of an ischemic event. Although it is known that genetics may play an important role in this pathology, the possible role of long non-coding RNAs (lncRNA) has never been studied. Therefore, the aim of this work is to study the expression of 10 lncRNAs in patients with and without VF in AMI. For this purpose, the expression of CDKN2B-AS1, KCNQ1OT1, LIPCAR, MALAT1, MIAT, NEAT1, SLC16A1-AS1, lnc-TK2-4:2, TNFRSF14-AS1, and UCA1 were analyzed. After the analysis and Bonferroni correction, the lncRNA CDKN2B-AS showed a statistical significance lower expression (P values of 2.514 x 10-5). In silico analysis revealed that six proteins could be related to the possible effect of lncRNA CDKN2B-AS1: AGO3, PLD4, POU4F1, ZNF26, ZNF326 and ZNF431. These in silico proteins predicted to have a low cardiac expression, although there is no literature indicating a potential relationship with VF in AMI. Thus, the lncRNA CDKN2B-AS1 shows a significant lower expression in patients with VF in AMI vs patients without VF in AMI. Literature data suggest that the role of CDKN2B1-AS is related to the miR-181a/SIRT1 pathway.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Mean expression level of the 10 studied lncRNA.
***: P value under 0.005.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Weizman O, Marijon E, Narayanan K, Boveda S, Defaye P, Martins R, et al.. Incidence, Characteristics, and Outcomes of Ventricular Fibrillation Complicating Acute Myocardial Infarction in Women Admitted Alive in the Hospital. Journal of the American Heart Association. 2022;11: e025959. doi: 10.1161/JAHA.122.025959 - DOI - PMC - PubMed
    1. Glinge C, Sattler S, Jabbari R, Tfelt-Hansen J. Epidemiology and genetics of ventricular fibrillation during acute myocardial infarction. J Geriatr Cardiol. 2016;13: 789–797. doi: 10.11909/j.issn.1671-5411.2016.09.006 - DOI - PMC - PubMed
    1. Deedwania P. Global risk assessment in the presymptomatic patient. Am J Cardiol. 2001;88: 17J–22J. doi: 10.1016/s0002-9149(01)01885-9 - DOI - PubMed
    1. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, et al.. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. European Heart Journal. 2015;36: 2793–2867. doi: 10.1093/eurheartj/ehv316 - DOI - PubMed
    1. Saliminejad K, Khorram Khorshid HR, Soleymani Fard S, Ghaffari SH. An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. J Cell Physiol. 2019;234: 5451–5465. doi: 10.1002/jcp.27486 - DOI - PubMed

Substances