Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 May 17:19:873-882.
doi: 10.2147/CIA.S457180. eCollection 2024.

Addressing the Missing Links in Cardiovascular Aging

Affiliations
Review

Addressing the Missing Links in Cardiovascular Aging

Elliot Dinetz et al. Clin Interv Aging. .

Erratum in

Abstract

The aim of this manuscript is to provide a review of available options to enhance cardiovascular health and prevent cardiovascular disease (CVD) in the aging population using a systems-biology approach. These include the role of the gut microbiome, the early identification and removal of environmental toxins, and finally age related sex hormones and supplement replacement which all influence aging. Implementing such a comprehensive approach has the potential to facilitate earlier risk assessment, disease prevention, and even improve mortality. Further study in these areas will continue to advance our understanding and refine therapeutic interventions for a healthier cardiovascular aging process.

Keywords: bioidentical hormone replacement; cardiovascular aging; inflammaging; microbiome; systems biology medicine; toxic metals; vascular aging.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Similar articles

Cited by

References

    1. Charo IF, Taub R. Anti-inflammatory therapeutics for the treatment of atherosclerosis. Nat Rev Drug Discov. 2011;10(5):365–376. PMID: 21532566; PMCID: PMC3947588. doi:10.1038/nrd3444 - DOI - PMC - PubMed
    1. Dhingra R, Vasan RS. Age as a risk factor. Med Clin North Am. 2012;96(1):87–91. PMID: 22391253; PMCID: PMC3297980. doi:10.1016/j.mcna.2011.11.003 - DOI - PMC - PubMed
    1. North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res. 2012;110(8):1097–1108. PMID: 22499900; PMCID: PMC3366686. doi:10.1161/CIRCRESAHA.111.246876 - DOI - PMC - PubMed
    1. Roth G, Mensah G, Johnson C, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: update From the GBD 2019 Study. Journal of the American College of Cardiology. 2020;76(25):2982–3021. doi:10.1016/j.jacc.2020.11.010 - DOI - PMC - PubMed
    1. Khot UN, Khot MB, Bajzer CT, et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA. 2003;290(7):898–904. doi:10.1001/jama.290.7.898 - DOI - PubMed

MeSH terms