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. 2024 May 20;70(5):e20231115.
doi: 10.1590/1806-9282.20231115. eCollection 2024.

Preoperative cancer antigen-125 levels as a predictor of recurrence in early-stage endometrial cancer

Anil Erturk  1 , Elmas Korkmaz  2 , Zeynep Arslantas  1 , Sena Bekdemir  1 , Nergis Kender Erturk  1
Affiliations

Preoperative cancer antigen-125 levels as a predictor of recurrence in early-stage endometrial cancer

Anil Erturk et al. Rev Assoc Med Bras (1992). .

Abstract

Objective: Endometrial cancer is the most common gynecological cancer in developed countries, with a majority of cases being low-grade endometrioid endometrial cancer. Identifying risk factors for disease recurrence and poor prognosis is critical. This study aimed to assess the correlation between preoperative cancer antigen-125 levels and disease recurrence in early-stage endometrioid endometrial cancer patients.

Methods: The study was a retrospective analysis of 217 patients diagnosed with endometrioid endometrial cancer who underwent surgical treatment at a university-affiliated tertiary hospital between 2016 and 2022. Patients were divided into two groups based on their preoperative cancer antigen-125 levels and compared with clinicopathological findings and disease recurrence. Disease-free survival rates were calculated, and logistic regression analysis was performed to determine independent factors affecting disease-free survival.

Results: The mean age of patients was 61.59±0.75 years, and the mean follow-up time was 36.95±1.18 months. The mean cancer antigen-125 level was 27.80±37.81 IU/mL. The recurrence rate was significantly higher in the group with elevated cancer antigen-125 levels (p=0.025). Disease-free survival was lower in patients with elevated cancer antigen-125 compared with those with normal levels (p=0.005). Logistic regression analysis revealed that elevated cancer antigen-125 levels were associated with disease recurrence (OR: 3.43, 95%CI 1.13-10.37, p=0.029).

Conclusion: The findings of this study suggest that preoperative cancer antigen-125 levels can be used as a predictor of disease recurrence in early-stage endometrioid endometrial cancer patients. cancer antigen-125 levels may be a useful tool for risk stratification and patient management in endometrial cancer.

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Conflict of interest statement

Conflicts of interest: the authors declare there is no conflicts of interest.

Figures

Figure 1
Figure 1. Kaplan-Meier survival analyses for disease-free survival in patients according to preoperative serum cancer antigen-125 levels. DFS: disease-free survival; m: months.
See this image and copyright information in PMC

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