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. 2024 Jul-Aug:128:107515.
doi: 10.1016/j.vascn.2024.107515. Epub 2024 May 20.

Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment

Todd A Wisialowski  1 , Nick Ether  2 , C Michael Foley  3 , Robert Kleiman  4 , Yevgeniya Koshman  3 , Derek Leishman  5 , Eric Martel  6 , Jill V Nichols  7 , Julia Popp  7 , Sridharan Rajamani  8 , Steve Riley  9 , Eric I Rossman  10 , Hugo M Vargas  2
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Free article

Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment

Todd A Wisialowski et al. J Pharmacol Toxicol Methods. 2024 Jul-Aug.
Free article
No abstract available

Keywords: Canine; Cardiovascular; Concentration-response modeling; ICH E14/S7B Q&As; In vivo; Moxifloxacin; Nonhuman primate; QTc prolongation; Safety pharmacology; Telemetry.

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Conflict of interest statement

Declaration of competing interest None of the authors has any conflicts of interest, other than their employment in commercial biopharmaceutical companies or contract research organizations (CROs). No information is presented in this paper that advocates for or promotes commercial products from any of our organizations.

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