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. 2024 Jun;10(6):478-480.
doi: 10.1016/j.trecan.2024.05.002. Epub 2024 May 22.

Intracranial CAR-T cell delivery in glioblastoma patients

Philippa Vaughn-Beaucaire  1 , Moon Jung Choi  2 , Olin Liang  2 , Sean E Lawler  3
Affiliations

Intracranial CAR-T cell delivery in glioblastoma patients

Philippa Vaughn-Beaucaire et al. Trends Cancer. 2024 Jun.

Abstract

Chimeric antigen receptor (CAR)-T cell therapy is emerging as a promising approach for improving outcomes in high-grade glioma. Here, we highlight three recent studies that reported safety and feasibility of intracranial CAR-T cell administration in patients with glioblastoma (GBM) as well as preliminary evidence of potential responses, supporting further investigations of this approach.

Keywords: CAR-T cells; clinical trial; glioblastoma; immunotherapy.

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Conflict of interest statement

Declaration of interests No interests are declared.

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