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. 2024 May 23;32(6):374.
doi: 10.1007/s00520-024-08572-6.

The prognostic value of immune-nutritional status in metastatic colorectal cancer: Prognostic Nutritional Index (PNI)

Merve Keskinkilic  1 , Huseyin Salih Semiz  2 , Evrim Ataca  3 , Tugba Yavuzsen  2
Affiliations

The prognostic value of immune-nutritional status in metastatic colorectal cancer: Prognostic Nutritional Index (PNI)

Merve Keskinkilic et al. Support Care Cancer. .

Abstract

Backround and purpose: A low Prognostic Nutritional Index (PNI) value, which reflects immune nutrition and inflammation around the tumor, is associated with an unfavorable prognosis, and it was aimed to reveal its prognostic value in metastatic colorectal cancer (CRC).

Methods: In our retrospective cross-sectional study, patients with a diagnosis of metastatic colorectal disease without active infection, between January 2010 and December 2016 were included. The PNI values at the time of diagnosis were calculated according to the formula (10 × serum albumin (g/dL)) + (0.005 × total lymphocyte value).

Results: The mean PNI value of 253 patients included in the study was 46.6. While 53.75% (n = 136) of the patients had a PNI value of 46.6 and above, 46.25% (n = 117) had a PNI value below 46.6. The overall survival (OS) of the group with a PNI of 46.6 and above was statistically significantly longer (53.06 months vs 38.80 months, p = 0.039). The PFS duration of the group with PNI below 46.6 was 25.66 months, while the PFS duration of the group with PNI above 46.6 was not reached (p = 0.265).

Conclusion: PNI is a simple and inexpensive index that evaluates the immunonutritional status, and it is a prognostic marker that can be easily used in patients with metastatic colorectal cancer as in other cancer types.

Keywords: Colorectal cancer (CRC); Immune status; Metastasis; Nutritional assessment; Prognostic factors.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
a, b Progression-free survival (PFS) and overall survival (OS) (all group)
Fig. 2
Fig. 2
Overall survival according to the PNI group
Fig. 3
Fig. 3
a, b According to tumor site overall survival (OS) in the PNI group
Fig. 4
Fig. 4
According to metastasis site overall survival in the PNI group
See this image and copyright information in PMC

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