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Review
. 2024 Aug;38(12):2267-2278.
doi: 10.1038/s41433-024-03136-8. Epub 2024 May 22.

Review of evidence for treatments of acute non arteritic anterior ischemic optic neuropathy

Pooja Parthasarathi  1 , Heather E Moss  2   3
Affiliations
Review

Review of evidence for treatments of acute non arteritic anterior ischemic optic neuropathy

Pooja Parthasarathi et al. Eye (Lond). 2024 Aug.

Abstract
in English, Chinese

Objective: To review treatment modalities that have been studied in acute non arteritic anterior ischemic optic neuropathy (NAION).

Methods: We performed a comprehensive literature search of English language publications in the last 5 years, with human species and NAION. Articles were reviewed to identify those that described original research on treatment of acute NAION. Study type, setting, duration, interventions, and results were extracted and articles were reviewed for biases and limitations.

Results: We identified 22 kinds of treatment varying by compound and modality. These include topical, intravitreal, and systemic drugs as well as surgical approaches. Evidence for efficacy ranges from expert opinion to randomized control trials.

Conclusions: Although several treatments are utilized in practice, none of these have high quality evidence of efficacy to improve visual outcomes. Continued collaborative research is necessary to complete high quality studies in order identify effective therapies for this rare and blinding disease.

摘要: 目的: 回顾急性非动脉炎性前部缺血性视神经病变 (NAION) 的治疗方法。方法: 我们对过去五年的英语文献进行全面检索, 检索词包括人类物种和NAION。通过回顾文献, 以确定描述急性NAION治疗的原始研究的文献。研究提取了研究类型、研究设计、持续时间、干预措施和结果, 并审查了文章的偏倚和局限性。结果: 我们确定了22种不同药物和治疗方法。其中包括局部、玻璃体内和全身药物以及手术方法。疗效证据包括专家意见到随机对照试验等。结论: 虽然几种治疗方法已用于实践, 但这些方法都没有高质量的疗效证据可改善视力效果。持续的合作研究对于完成高质量的研究是必要的, 以确定这种罕见和致盲疾病的有效疗法。.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Flow chart depicting the various treatments that have been studied, proposed, or utilized for acute NAION.
Thick border indicates that an RCT has been conducted. No border indicates that there are no published human studies available.
See this image and copyright information in PMC

References

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