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Case Reports
. 2024 May 6:12:531-533.
doi: 10.1016/j.toxrep.2024.04.012. eCollection 2024 Jun.

Traditional cheese consumption leading to hemodialysis induced by rifampin treatment: A case report

Milad Ahangarzadeh  1 , Razieh Janghiyamachi  2 , Kamal Rahimi  3 , Behnam Babamiri  4 , Mahin Roohani  5 , Hiva Lotfy  6 , Rasoul Goli  4 , Navid Faraji  4 , Mohammad Reza Faramarzi  1 , Ali Mesri  3
Affiliations
Case Reports

Traditional cheese consumption leading to hemodialysis induced by rifampin treatment: A case report

Milad Ahangarzadeh et al. Toxicol Rep. .

Abstract

This case report details the journey of a 51-year-old man residing in a remote Iranian village, involved in livestock rearing, who was hospitalized due to Brucellosis contracted from consuming traditional cheese and dairy products. Initially treated with doxycycline and rifampin, complications arose during antituberculosis therapy, with the patient developing symptoms of nausea, vomiting, and edema alongside renal function deterioration necessitating medication cessation. Subsequent manifestations of proteinuria, toxic hepatitis, and nephrotic syndrome prompted renal biopsy, revealing drug-induced glomerular and tubular damage. Swift cessation of rifampicin, combined with prednisolone therapy, led to symptom amelioration, resulting in the cessation of dialysis and the patient's discharge within three weeks. This case underscores the intricate relationship between traditional cheese consumption, medication-induced renal complications, and the importance of timely intervention and appropriate management in achieving a successful patient outcome.

Keywords: Brucellosis; Cheese; Hemodialysis; Renal failure; Rifampin.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

None
Graphical abstract
Fig. 1
Fig. 1
Renal biopsy histology showed a glomerulus with moderate initial segmental sclerosis and intense interstitial inflammation marked by lymphocytes and granulocytes.
See this image and copyright information in PMC

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